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ProteomicsThe Functions of Serine 687 Phosphorylation of Human DNA Polymerase eta in UV Damage Tolerance
DNA polymerase (pol) is a Y-family translesion synthesis polymerase that plays a key role in the cellular tolerance toward UV irradiation-induced DNA damage. Here, we identified, for the first time, the phosphorylation of serine 687 (S687), which islocated in the highly conserved nuclear localizati...
ORGANISM(S): Homo sapiens (Human) 
2016-07-19 | PXD002946 | Pride
Translesion synthesis Cdk2 Dna polymerase eta 
GenomicsDNA polymerase η contributes to lagging strand synthesis
DNA polymerase η contributes to lagging strand synthesis
PRJNA433239 | ENA
OtherDNA polymerase η contributes to lagging strand synthesis
DNA polymerase eta (pol eta) is best known for its ability to bypass UV-induced thymine-thymine (T-T) dimers and other bulky DNA lesions, but pol eta also has other cellular roles. Here, we present evidence that pol eta competes with DNA polymerases alpha and delta for the synthesis of the lagging s...
ORGANISM(S): Saccharomyces cerevisiae 
2018-12-14 | GSE110241 | GEO
GenomicsStrand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis [ChIP-Seq]
Efficient eukaryotic DNA replication relies on the coordinated actions of replicative and error-prone polymerases, with the latter providing flexibility at the cost of mutagenesis. DNA polymerase η (Pol η) is most recognised for tolerating UV-induced DNA damage via translesion synthesis (TLS). Howev...
ORGANISM(S): Homo sapiens 
2026-08-27 | GSE308762 | GEO
OtherStrand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis [Pu-seq].
Efficient eukaryotic DNA replication relies on the coordinated actions of replicative and error-prone polymerases, with the latter providing flexibility at the cost of mutagenesis. DNA polymerase η (Pol η) is most recognised for tolerating UV-induced DNA damage via translesion synthesis (TLS). Howev...
ORGANISM(S): Homo sapiens 
2026-08-27 | GSE308763 | GEO
GenomicsStrand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis [ChIP-Seq]
Strand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis [ChIP-Seq]
PRJNA1332677 | ENA
GenomicsStrand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis [Pu-seq].
Strand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis [Pu-seq].
PRJNA1332678 | ENA
UnknownUnlocking the steric gate of DNA polymerase η leads to increased genomic instability in Saccharomyces cerevisiae.
Not available
S-EPMC4651834 | biostudies-literature
UnknownHuman DNA polymerase η accommodates RNA for strand extension.
Not available
S-EPMC5672030 | biostudies-literature
UnknownHuman DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks.
Not available
S-EPMC10011834 | biostudies-literature
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