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TranscriptomicsInactivation of CDK2 is synthetic lethal to MYCN-overexpressing cancer cells
Two genes have a synthetic lethal relationship when silencing or inhibition of one gene is only lethal in the context of a mutation or activation of the second gene. This situation offers an attractive therapeutic strategy, as inhibition of such a gene will only trigger cell death in tumor cells wit...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-16480 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of OVCAR-3 and CDK2 resistant sublines
Cyclin E1 (CCNE1) is amplified in various tumor types including high-grade serous ovarian cancer where it is associated with poor clinical outcome. We have demonstrate that suppression of the Cyclin E1 partner kinase, CDK2, induces apoptosis in a CCNE1 amplicon-dependent manner. Little is known of m...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-48919 | biostudies-arrayexpress
TranscriptomicsCopy number analysis of OVCAR-3 and CDK2 resistant sublines
Cyclin E1 (CCNE1) is amplified in various tumor types including high-grade serous ovarian cancer where it is associated with poor clinical outcome. We have demonstrate that suppression of the Cyclin E1 partner kinase, CDK2, induces apoptosis in a CCNE1 amplicon-dependent manner. Little is known of m...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-48920 | biostudies-arrayexpress
TranscriptomicsRNA-seq data of wildtype, CDK2-knockdown and JUN-knockdown THP1 cells treated with LPS against untreated controls
RNA-seq was performed to identify differences in the transcriptome between wildtype, CDK2-knockdown and JUN-knockdown THP1 cells treated with LPS against untreated controls.
ORGANISM(S): Homo sapiens 
2022-07-04 | E-MTAB-11872 | biostudies-arrayexpress
ModelsConradie2010_RPControl_CellCycle
This model is from the article: Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex. Conradie R, Bruggeman FJ, Ciliberto A, Csikász-Nagy A, Novák B, Westerhoff HV, Snoep JL FEBS J.2010 Jan; 277(2): 357-67 20015233, ...
2024-09-02 | BIOMD0000000265 | BioModels
TranscriptomicsGene expression and copy number analysis of OVCAR-3 and CDK2 resistant sublines
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-48921 | biostudies-arrayexpress
ProteomicsMass Spectrum analysis to identify the interacting proteins with CDK2 induced by HHT treatment.
Mass Spectrum analysis to identify the interacting proteins with CDK2 induced by HHT treatment.
ORGANISM(S): Homo sapiens (Human) 
2022-04-18 | PXD031914 | Pride
Aml Hht Cdk2 
TranscriptomicsExpression data from renal primary epithelial cells
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of multiple fluid-filled cysts that destroy the kidney architecture resulting in end-stage renal failure. Mutations in the ADPKD genes PKD1 and PKD2 account for nearly all the cases of ADPKD. Increased cell prolif...
ORGANISM(S): Rattus norvegicus 
2010-05-19 | E-GEOD-11500 | biostudies-arrayexpress
ProteomicsSARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis
The coronavirus disease 2019 (COVID-19) pandemic has devastated global health. Identifying key host factors essential for SARS-CoV-2 RNA replication is expected to unravel cellular targets for the development of broad-spectrum antiviral drugs which have been quested for the preparedness of future vi...
ORGANISM(S): Homo Sapiens 
PXD037068 |
ProteomicsIn vitro phosphorylation of ASY1 by CDKA;1
Meiosis is a complex cell division program reducing chromosome number as a prerequisite for sexual reproduction and at the same time leading to a new combination of parental alleles contributing to biodiversity. Little is known about how the distinct order of the molecular processes of meiosis are o...
ORGANISM(S): Arabidopsis Thaliana 
2019-10-01 | PXD011335 | panorama
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