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MetabolomicsB-cell Translocation Gene 2 Inhibits UFMylation Modification of FMO1 thus Restricting Taurine Synthesis and Exacerbating Ferroptosis in Hepatic Ischemia-Reperfusion Injury

Hepatic ischemia-reperfusion (I/R) injury is a common complication occurs during liver transplantation. However, the mechanisms underlying hepatic I/R injury have not been fully elucidated. B-cell translocation gene 2 (Btg2) has been implicated in the development of various diseases. However, its...

2026-03-07 | MTBLS11677 | MetaboLights
GenomicsDNA-PKcs suppress chromosome translocation in human cells
DNA-PKcs suppress chromosome translocation in human cells
PRJNA974458 | ENA
ProteomicsSTIM1 Translocation to The Nucleus Protects Cells from DNA Damage
DNA damage represents a challenge for cells as this damage must be eliminated to preserve cell viability and the transmission of genetic information. To reduce or eliminate unscheduled chemical modifications in genomic DNA, an extensive signaling network, known as the DNA damage response (DDR) pathw...
ORGANISM(S): Homo sapiens (Human) 
2023-12-22 | PXD041181 | Pride
Dna repair  double strand breaks  fanconi anemia  nucleus  stim1 
TranscriptomicsOrientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching
During B cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segments and orchestrates their fusion as deletional events that assemble a V(D)J exon in the same transcriptional orientation as adjacent Cμ constant region exons. In mice, six additional sets of c...
ORGANISM(S): Mus musculus 
2015-08-26 | E-GEOD-71005 | biostudies-arrayexpress
GenomicsERCC6L2 suppresses chromosome translocation
ERCC6L2 suppresses chromosome translocation
PRJNA1184159 | ENA
ProteomicsBTG3-dependent VCP/p97 nuclear translocation is required for efficient repair of UV-induced DNA lesions
Skin exposure to ultraviolet (UV) rays from sunlight results in the formation of mutagenic DNA photolesions that are repaired by the nucleotide excision repair (NER) machinery. The inefficient repair of photolesions can lead to stalled DNA replication and mispairing, thereby causing strand breaks an...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD056446 | Pride
Phosphorylation Lc-ms/ms 
ProteomicsMaximizing Confidence and Sensitivity in Phosphoproteomics reveals novel targets of DNA damage signling Kinases
Proteome-wide analysis of phosphorylation events is a challenging, yet essential, task for the comprehensive and unbiased investigation of kinase action. Here we developed a phosphoproteomic approach in which quantitation consistency among reversed isotopically labeled samples is used as a central f...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2020-01-24 | MSV000084839 | MassIVE
UnknownTranslocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes.
Not available
S-EPMC4636054 | biostudies-literature
GenomicsCharacterization of Oral-to-Blood Microbial DNA Translocation in Chronic Cocaine Use Disorder
Characterization of Oral-to-Blood Microbial DNA Translocation in Chronic Cocaine Use Disorder
PRJNA1301822 | ENA
GenomicsGadd45a promotes DNA demethylation through TDG
Growth arrest and DNA-damage-inducible protein 45 (Gadd45) family members have been implicated in DNA demethylation in vertebrates. However, it remained unclear how they contribute to the demethylation process. Here, we demonstrate that Gadd45a promotes active DNA demethylation through thymine DNA g...
ORGANISM(S): Mus musculus 
2015-05-07 | E-GEOD-62496 | biostudies-arrayexpress
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