Sort   by:  
 Page size 
ProteomicsProteome analysis of i-motif DNA binding proteins
Non-canonical DNA structures such as G-quadruplex (G4) and i-motif (iM) are formed at the guanine- and cytosine-rich sequences, respectively, and prohibit DNA replication and transcription. The formation and resolution of these non-canonical structures are therefore required to be dynamically regula...
ORGANISM(S): Homo Sapiens (human) 
2024-10-15 | PXD051188 | JPOST Repository
ProteomicsNucleosome binding by the pioneer transcription factor OCT4
The nucleosome is a fundamental unit of chromatin in eukaryotes, and generally prevents the binding of transcription factors to genomic DNA. Pioneer transcription factors overcome the nucleosome barrier, and bind their target DNA sequences in chromatin. OCT4 is a representative pioneer transcription...
ORGANISM(S): Homo Sapiens (human) 
2020-05-13 | PXD019160 | JPOST Repository
TranscriptomicsDNA binding factors shape the mouse methylome at distal regulatory regions.
This SuperSeries is composed of the following subset Series: GSE30202: DNA binding factors shape the mouse methylome at distal regulatory regions [BIS_seq] GSE30203: DNA binding factors shape the mouse methylome at distal regulatory regions [ChIP-seq] GSE30204: DNA binding factors shape the mouse me...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-30206 | biostudies-arrayexpress
GenomicsMultiplexed identification of the genomic targets of DNA-binding proteins
Transcription factors direct gene expression, and so there is much interest in mapping their genome-wide binding locations. M-BM- Current methods do not allow for the multiplexed analysis of TF binding, and this limits their throughput. We describe a novel method for determining the genomic target g...
ORGANISM(S): Saccharomyces cerevisiae 
2011-02-18 | E-GEOD-27381 | biostudies-arrayexpress
TranscriptomicsQuantitative modeling of transcription factor binding specificities using DNA shape
Accurate predictions of the DNA binding specificities of transcription factors (TFs) are necessary for understanding gene regulatory mechanisms. Traditionally, predictive models are built based on nucleotide sequence features. Here, we employed three- dimensional DNA shape information obtained on a ...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-59845 | biostudies-arrayexpress
TranscriptomicsDNA binding factors shape the mouse methylome at distal regulatory regions [RNA_seq]
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-22 | E-GEOD-30280 | biostudies-arrayexpress
TranscriptomicsDNA binding factors shape the mouse methylome at distal regulatory regions [ChIP_chip]
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-30204 | biostudies-arrayexpress
ProteomicsComparative analysis of PRE DNA-binding factors interactomes: purification of Combgap, Zeste, Psq and Adf1 associated proteins
The Polycomb group (PcG) and Trithorax group (TrxG) proteins are key epigenetic regulators controlling silenced and active states of genes in multicellular organisms, respectively. In Drosophila PcG/TrxG proteins are recruited to chromatin via binding to specialized DNA-elements termed Polycomb Resp...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-05-22 | PXD029459 | Pride
Interactomes Dna-binding factors Drosophila melanogaster Lc-ms/ms 
TranscriptomicsDNA binding factors shape the mouse methylome at distal regulatory regions [strand-specific-RNA-seq]
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-31385 | biostudies-arrayexpress
GenomicsDNA binding factors shape the mouse methylome at distal regulatory regions [ChIP-seq].
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-30203 | biostudies-arrayexpress
Sort   by:  
 Page size