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ProteomicsThe Escherichia coli replication initiator DnaA is titrated on the chromosome
DNA replication initiation is orchestrated in bacteria by the replication initiator DnaA. Two models for regulation of DnaA activity in Escherichia coli have been proposed: the switch between an active and inactive form and the titration of DnaA on the chromosome. Although proposed decades ago, expe...
ORGANISM(S): Escherichia coli 
2025-07-28 | PXD064841 | Pride
Titration model Single-particle tracking photoactivatable localisation microscopy Switch model Dnaa protein Oric Dnaa boxes chromosome binding Data Replication initiator 
GenomicsChIP-seq experiment: DnaA binding to E. coli chromosome before stress, during stress, and stress recovery
The ubiquitous protein DnaA is a chromosomal DNA replication initiator and transcription factor. It binds to 9-bp DNA sites called \"DnaA-boxes\" that are localized within the replication origin (oriC) and throughout chromosomal DNA, usually in the proximity of the promoter regions. During stress, b...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2026-03-13 | E-MTAB-14964 | biostudies-arrayexpress
GenomicsChIP-seq experiment: DnaA binding to E. coli chromosome before stress, during stress, and stress recovery
ChIP-seq experiment: DnaA binding to E. coli chromosome before stress, during stress, and stress recovery
PRJEB87391 | ENA
UnknownUnique and Universal Features of Epsilonproteobacterial Origins of Chromosome Replication and DnaA-DnaA Box Interactions.
Not available
S-EPMC5043019 | biostudies-literature
UnknownPutative Cooperative ATP-DnaA Binding to Double-Stranded DnaA Box and Single-Stranded DnaA-Trio Motif upon Helicobacter pylori Replication Initiation Complex Assembly.
Not available
S-EPMC8235120 | biostudies-literature
UnknownIdentification of a putative chromosomal replication origin from Helicobacter pylori and its interaction with the initiator protein DnaA.
Not available
S-EPMC55718 | biostudies-literature
UnknownGenetic and biochemical interactions between the bacterial replication initiator DnaA and the nucleoid-associated protein Rok in Bacillus subtilis.
Not available
S-EPMC5323315 | biostudies-literature
UnknownStructure and Function of the Campylobacter jejuni Chromosome Replication Origin.
Not available
S-EPMC6052347 | biostudies-literature
UnknownEvidence for a chromosome origin unwinding system broadly conserved in bacteria.
Not available
S-EPMC8287927 | biostudies-literature
UnknownHelicobacter pylori oriC--the first bipartite origin of chromosome replication in Gram-negative bacteria.
Not available
S-EPMC3479198 | biostudies-literature
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