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TranscriptomicsThermoprotection in the Drosophila hsf4 mutant
In Drosophila larvae, acquired synaptic thermotolerance following heat shock has previously been shown to correlate with the induction of heat shock proteins (Hsps) including HSP70. We tested the hypothesis that synaptic thermotolerance would be significantly diminished in a temperature-sensitive st...
ORGANISM(S): Drosophila melanogaster 
2005-11-30 | E-GEOD-2998 | biostudies-arrayexpress
GenomicsDNAJ-PKAc Induces Metabolic Rewiring and a Glutamine Dependency in Fibrolamellar HCC
DNAJ-PKAc Induces Metabolic Rewiring and a Glutamine Dependency in Fibrolamellar HCC
PRJNA1304424 | ENA
GenomicsCentrosomal Localization of DNAJ-PKAc Fusion Heightens PLK1 Inhibitor Sensitivity in Fibrolamellar Cancer
Centrosomal Localization of DNAJ-PKAc Fusion Heightens PLK1 Inhibitor Sensitivity in Fibrolamellar Cancer
PRJNA1051952 | ENA
TranscriptomicsDNAJ-PKAc Induces Metabolic Rewiring and a Glutamine Dependency in Fibrolamellar HCC
Background: Fibrolamellar carcinoma (FLC) is a pediatric and adolescent liver cancer that is characterized by a recurrent fusion of DNAJB1 and PRKACA, yielding a chimeric translated protein, DNAJ-PKAc. PRKACA encodes the catalytic subunit of protein kinase A (PKA), a regulator of cellular metabolism...
ORGANISM(S): Mus musculus 
2026-05-15 | GSE305096 | GEO
TranscriptomicsCentrosomal Localization of DNAJ-PKAc Fusion Heightens PLK1 Inhibitor Sensitivity in Fibrolamellar Cancer
Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ-PKAc fusion oncoprotein. However, the underlying mechanism of DNAJ-PKAc's role in FLC tumor growth remains enigmatic. Employing an unbiased systems-based approach, we uncovered a new ro...
ORGANISM(S): Homo sapiens 
2023-12-19 | GSE250059 | GEO
ProteomicsAn acquired scaffolding function of the DNAJ-PKAc fusion enhances oncogenesis in Fibrolamellar carcinoma
Fibrolamellar carcinoma (FLC) is a rare liver cancer. FLC tumors exclusively produce DNAJ-PKAc, a de novo chimeric enzyme consisting of a chaperonin-binding domain fused to the C subunit of protein kinase A. Biochemical analyses of clinical samples reveal that a unique property of DNAJ-PKAc is the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2018-11-27 | MSV000083167 | MassIVE
UnknownDnaJ, a promising vaccine candidate against Ureaplasma urealyticum infection.
Not available
S-EPMC9589543 | biostudies-literature
ProteomicsRecruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma
Raw MS datafiles and MaxQuant search result files for Lauer et. al. "Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-07-13 | MSV000092440 | MassIVE
UnknownDNAJ Proteins in neurodegeneration: essential and protective factors.
Not available
S-EPMC5717533 | biostudies-literature
UnknownComputational analysis of the human HSPH/HSPA/DNAJ family and cloning of a human HSPH/HSPA/DNAJ expression library.
Not available
S-EPMC2673897 | biostudies-literature
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