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TranscriptomicsSyngergistic Effect of JQ1 and Rapamycin for Treatment of Human Osteosarcoma
Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1, a BET protein inhibitor, has antiproliferative activity against many cancers, mainly through inhibition of c-MYC ...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-57203 | biostudies-arrayexpress
TranscriptomicsAnaplastic thyroid carcinoma cell lines (HTH83 and TL3) infected with LAMC2 shRNA
Laminin-5 gamma-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and associated with tumor progression, migration and invasion by modulating signaling of EGFR LAMC2 was highly expressed in ATC samples and cell lines compared to normal thyroid tissues. Silencing LAMC2 by shRNA in ATC cel...
ORGANISM(S): Homo sapiens 
2013-10-10 | E-GEOD-50767 | biostudies-arrayexpress
TranscriptomicsBCL6 enforces human glioblastoma growth and serves as a novel therapeutic target (expression)
ZBTB transcription factors extensively orchestrate gene transcription during tissue development. However, their roles in glioblastoma multiforme (GBM) remain largely unexplored. Here, through integrated functional screening and expression analyses of 49 human ZBTB genes, we identify that BCL6 is req...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-77053 | biostudies-arrayexpress
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