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TranscriptomicsPromoter activity profiling throughout the Drosophila life cycle reveals role of transposons in regulatory innovation
Since their discovery, transposable elements have been proposed to play a central role in the evolution of their host genomes through their ability to regulate gene expression, in particular by providing transcription start sites (TSSs) for host genes. To investigate their contribution to developmen...
ORGANISM(S): Drosophila melanogaster 
2012-08-30 | E-GEOD-36212 | biostudies-arrayexpress
TranscriptomicsRAMPAGE dataset for the human K562 cell line
5'-complete cDNA sequencing on ribosome-depleted total RNA from the human K562 cell line. Provides high-quality, genome-wide single-base resolution profiling of transcription start sites and their expression levels. This dataset represents a whole-genome, single-base resolution profiling of transcri...
ORGANISM(S): Homo sapiens 
2012-08-30 | E-GEOD-36200 | biostudies-arrayexpress
TranscriptomicsA multi-scale approach reveals that NFkB cRel enforces a B-cell decision to divide.
The transcriptomes of individual small and large B cells after 24 h of stimulation were sequenced and genes upregulated in small or large cells were found and analyzed to provide a global charactarization of transcription patterns in growing B cells. We identified 5 large and 5 small viable B cells ...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-64156 | biostudies-arrayexpress
TranscriptomicsTotal RNAseq of human healthy control inferior turbinate and glucocorticoid-treated, NSAID-exacerbated respiratory disease (N-ERD) nasal polyp nasal brushings
NSAID-exacerbated respiratory disease (N-ERD) represents a particularly severe endotype of chronic rhinosinusitis with nasal polyps (CRSwNP), which affects around 10-16% of CRSwNP patients. N-ERD is characterized by severe and refractory nasal polyposis, bronchial asthma and intolerance to non-stero...
ORGANISM(S): Homo sapiens 
2020-06-30 | E-MTAB-7962 | biostudies-arrayexpress
TranscriptomicsscRNA-seq analysis of enriched CD4+ T cells from lung tissues after single or combined AIT treatment strategies with AhR agonist 10-Cl-BBQ in a murine model of OVA-induced allergic airway inflammation (AAI)
Allergen-specific immunotherapy (AIT) is able to restore immune tolerance to allergens in allergic patients. However, some patients do not or only poorly respond to current treatment protocols. Therefore, there is a need for deeper mechanistic insights and further improvement of treatment strategies...
ORGANISM(S): Mus musculus 
2024-05-06 | E-MTAB-14030 | biostudies-arrayexpress
TranscriptomicsAltering the intestinal microbiota during a critical developmental window has lasting metabolic consequences [RNA-Seq]
Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), ...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-58089 | biostudies-arrayexpress
TranscriptomicsmRNAseq of human sputum macrophages and alveolar-like monocyte-derived macrophages of healthy controls and NSAID-exacerbated respiratory disease (N-ERD) patients
NSAID-exacerbated respiratory disease (N-ERD) represents a particularly severe endotype of chronic rhinosinusitis with nasal polyps (CRSwNP), which affects around 10-16% of CRSwNP patients. N-ERD is characterized by severe and refractory nasal polyposis, bronchial asthma and intolerance to non-stero...
ORGANISM(S): Homo sapiens 
2020-06-30 | E-MTAB-7965 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of early differentiation of primary human mesenchymal stem cells into chondrocytes
Transcriptional profiling of undifferentiated MSCs, MSCs in 3D culture, early differentiation time-points 15m, 30m, 1h, 2h, 4h, 8h, 16h after induction with TGF-β3 and hyaluronic acid, and fully differentiated chondrocytes (21 days after induction) using RNA-seq in triplicates of clones.
ORGANISM(S): Homo sapiens 
2021-05-24 | E-MTAB-10476 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of MBP-specific T cells during experimental autoimmune encephalomyelitis
2nd generation sequencing was used to compare expression profiles of MBP-specific T cells retrieved from blood, CSF, spinal cord meninges and parenchyma. The overall expression profiles were found to be very similar.However, genes regulated during T cell activation were found to be upregulated in T ...
ORGANISM(S): Rattus norvegicus 
2016-02-12 | E-GEOD-75488 | biostudies-arrayexpress
UnknownComparative analysis of the transcriptome across distant species.
Not available
S-EPMC4155737 | biostudies-literature
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