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TranscriptomicsTranscription profiling of two human colon cancer cell lines treated with n-3 PUFA docosahexaenoic acid for 3 different time points
Several studies indicate that omega (n)-3 fatty acids may have a potential in the prevention and treatment of cancer. In this study the colon cancer cell lines SW480 and SW620 were treated with the n-3 PUFA DHA (Docosahexaenoic acid) for 3 different time points (12, 24 and 48h). The experiments were...
ORGANISM(S): Homo sapiens 
2008-04-01 | E-MEXP-1014 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of blood cells from hypertriglyceridemic men treated with docosahexaenoic acid shows suppression of LDLR and OLR1 gene expression.
Previously published results from our double-blind, placebo-controlled parallel study with docosahexaenoic acid (DHA) supplementation (3 g/d, 90 d) to hypertriglyceridemic men (39-66yr) showed that DHA reduced several risk factors for cardiovascular disease (CVD), including the plasma concentration ...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-20114 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colon cancer cell line SW620 treated with docosahexaenoic acid
The human colon cancer cell line SW620 was supplemented with DHA (70 µM) or an equal volume of ethanol (control). Total RNA was isolated after 6 h and used for Affymetrix gene expression profiling.
ORGANISM(S): Homo sapiens 
2009-06-01 | E-MEXP-2010 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cultured rat cardiomyocytes grown with eicosapentaenoic acid or docosahexaenoic acid supplementation in the culture media
Despite the recognized protective effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in cardiovascular diseases, and the demonstration of the control of gene expression by polyunsaturated fatty acids (PUFAs), the effects of these n-3 fatty acids on the whole genoma has never been ...
ORGANISM(S): Rattus norvegicus 
2008-05-07 | E-GEOD-4327 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Baboon (Papio anubis) cerebral cortex from neonates consuming long-chain polyunsaturated fatty acid formulas
Docosahexaenoic acid (DHA, 22:6n-3) and arachidonic acid (ARA, 20:4n-6) are the major long chain polyunsaturated fatty acids (LCPUFA) of the central nervous system. We examined the alterations in transcriptional profiles in neonate baboon cerebral cortex brain tissue using high-density Affymetrix ol...
ORGANISM(S): Papio anubis 
2007-10-25 | E-GEOD-6519 | biostudies-arrayexpress
TranscriptomicsEffects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study
The hypothesis was that 6 months of dietary n-3 FA supplementation to humans affected expression of genes that might be of significance for inflammatory processes and for Alzheimer´s disease. Effects on global gene expression profiles (Affymetrix Human Focus array) in human blood mononuclear leukocy...
ORGANISM(S): Homo sapiens 
2012-05-23 | E-GEOD-29680 | biostudies-arrayexpress
ProteomicsDocosahexaenoic acid attenuates metabolic dysfunctions induced by lipopolysaccharide in BV-2 microglial cells
Microglial cell activation has been linked to many neurodegenerative diseases. Upon stimulation by lipopolysaccharide (LPS), a number of proteins involved in inflammatory and oxidative pathways are activated. Production of nitric oxide has been regarded as a signature marker of inflammatory response...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-20 | PXD013086 | Pride
Lipopolysaccharide Tims Docosahexaenoic acid Label-free quantification Microglia Time-of-flight. Ion mobility 
ProteomicsSWATH differential abundance proteomics and cellular assays show in vitro anticancer activity of arachidonic and docosahexaenoic acid monoacylglycerols in HT-29 colorectal cancer cell line
Colorectal cancer (CRC) is one of the most common and mortal types of cancer. There is increasing evidence that some polyunsaturated fatty acids (PUFA) exercise specific inhibitory actions on cancer cells through different mechanisms, as a previous study on the effect on CRC cells of two PUFA free f...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD014874 | Pride
Colorectal cancer  proteomics  swath  monoacylglycerol  docosahexaenoic acid  arachidonic acid. 
MetabolomicsEvidence of a DHA signature in the lipidome and metabolome of human hepatocytes
Cell supplementation with bioactive molecules often causes a perturbation in the whole intracellular environment. Omics techniques can be applied for the assessment of this perturbation. In this study, the overall effect of docosahexaenoic acid (DHA) supplementation on cultured human hepatocyte lipi...
2017-03-02 | MTBLS419 | MetaboLights
TranscriptomicsGene expression profiling/transcription analyses of ARPE-19 cells after docosahexaenoic acid treatment
A global gene expression profiling of ARPE-19 cells after supplementation of DHA or vehicle for 1, 3, 6, 12 and 24 h to determine differentially expressed transcripts.
ORGANISM(S): Homo sapiens 
2014-10-31 | E-MTAB-3016 | biostudies-arrayexpress
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