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TranscriptomicsRNA-Seq analysis of ada2M-NM-^T, nrg1M-NM-^T and cir1M-NM-^T and KN99M-NM-1 wildtype cells in capsule inducing and non-inducing conditions
To contextualize the cryptococcal Spt-Ada-Gcn5 Acetyltransferase (SAGA) member Ada2 in the capsule regulatory network, RNA-Seq was performed on wildtype, ada2M-NM-^T and two other transcription factors, nrg1M-NM-^T and cir1M-NM-^T, which like ada2M-NM-^T are also defective for capsule formation, vir...
ORGANISM(S): Cryptococcus neoformans 
2012-01-01 | E-GEOD-32049 | biostudies-arrayexpress
GenomicsChIP-Seq of H3K9 acetylation for wildtype and ada2Δ cells in Cryptococcus neoformans
SAGA member Ada2 is required for the majority of H3K9 acetylation in C. neoformans. To identify specific genomic loci that exhibit Ada2-dependent H3K9 acetylation, we performed ChIP-Seq against H3K9ac in wildtype and ada2Δ cells. ChIP-Seq was performed using antibodies for H3K9ac in KN99 wildtype ce...
ORGANISM(S): Cryptococcus neoformans 
2012-01-01 | E-GEOD-32075 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of macrophages from conventional or antibiotic-treated mice
Antibiotic-treated (ABX) mice exhibit an impaired innate and adaptive antiviral immune response and substantially delayed viral clearance following exposure to systemic LCMV or mucosal influenza virus. Genome-wide transcriptional profiling of macrophages isolated from ABX mice revealed decreased ex...
ORGANISM(S): Mus musculus 
2015-11-05 | E-GEOD-74712 | biostudies-arrayexpress
TranscriptomicsModel-driven mapping of transcriptional networks reveals the circuitry and dynamics of virulence regulation
Purpose: Key steps in understanding a biological process include identifying genes that are involved and determining how they are regulated. We developed a novel method for identifying TFs involved in a specific process and used it to map regulation of the key virulence factor of Cryptococcus neofor...
ORGANISM(S): Cryptococcus neoformans 
2015-01-14 | E-GEOD-60398 | biostudies-arrayexpress
TranscriptomicsUsv101 is a key regulator of cryptococcal virulence and determinant of host response
Cryptococcus neoformans is a fungal pathogen responsible for hundreds of thousands of deaths per year. Its critical virulence factor is a polysacharride capsule which grows large upon entry into a mammalian host. We previously identified USV101 as a transcription factor whose deletion results in enl...
ORGANISM(S): Cryptococcus neoformans 
2016-03-31 | E-GEOD-69532 | biostudies-arrayexpress
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