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TranscriptomicsPolycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network [RNA-Seq]
Malignant gliomas constitute one of the most significant areas of unmet medical need, due to the invariable failure of surgical eradication and their marked molecular heterogeneity. Accumulating evidence has revealed a critical contribution by the Polycomb axis of epigenetic repression. However, a c...
ORGANISM(S): Mus musculus 
2016-03-02 | E-GEOD-76291 | biostudies-arrayexpress
GenomicsPolycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network [ChIP-Seq]
Malignant gliomas constitute one of the most significant areas of unmet medical need, due to the invariable failure of surgical eradication and their marked molecular heterogeneity. Accumulating evidence has revealed a critical contribution by the Polycomb axis of epigenetic repression. However, a c...
ORGANISM(S): Mus musculus 
2016-03-02 | E-GEOD-76289 | biostudies-arrayexpress
GenomicsGenome-wide maps of chromatin state in Germinal Center B cells.
Protection against deadly pathogens requires the production of high-affinity antibodies by B cells. High-affinity antibody-forming cells are generated in germinal centers (GC) as a result of a developmental program that is commonly altered in B cell malignancies. Identification of regulators of the ...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-50912 | biostudies-arrayexpress
TranscriptomicsLentiviral vector-based insertional mutagenesis identifies new clinically relevant candidate cancer genes involved in the pathogenesis of hepatocellular carcinoma
We devised a novel insertional mutagenesis approach based on lentiviral vectors to induce hepatocellular carcinoma in three mouse models and identified four novel cancer initiating genes. Two genes are the well characterized Braf and Sos1, while the other two are Fign, encoding an AAA ATPase whose f...
ORGANISM(S): Homo sapiens 
2015-02-19 | E-GEOD-35986 | biostudies-arrayexpress
TranscriptomicsLentiviral vector-based insertional mutagenesis identifies new clinically relevant cancer genes involved in the pathogenesis of hepatocellular carcinoma
We devised a novel insertional mutagenesis approach based on lentiviral vectors to induce hepatocellular carcinoma in three mouse models and identified four novel cancer initiating genes. Two genes are the well characterized Braf and Sos1, while the other two are Fign, encoding an AAA ATPase whose f...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-31409 | biostudies-arrayexpress
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