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GenomicsGata6 network regulates epidermal junctional zone cell fate.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2017-05-16 | E-GEOD-62608 | biostudies-arrayexpress
GenomicsGenome-wide maps of Gata6 in primary mouse keratinocytes
In adult K14Î?NLef1 mouse, the overexpression of â??NLef1, a Ã?-catenin dominat negative, in basal keratinocytes leads to the conversion of hair follicles into multilayered epithelial cysts and ectopic sebaceous gland. â??NLef1 transcriptional activity led to Gata6 overexpression in the pilosebaceou...
ORGANISM(S): Mus musculus 
2017-05-16 | E-GEOD-62607 | biostudies-arrayexpress
TranscriptomicsGene expression signature of Gata6 positive epidermal cells.
To characterize gene expression in Gata6 positive epidermal cells we analyzed a Gata6 reporter mouse in which the endogenous Gata6 promoter drives expression of mTomato. We performed flow cytometry followed by transcriptome analysis. We compared four subpopulations of telogen epidermal cells: Gata6+...
ORGANISM(S): Mus musculus 
2017-05-16 | E-GEOD-62606 | biostudies-arrayexpress
TranscriptomicsGene expression signature of the three major epidermal differentiation compartments: interfollicular epidermis (IFE), hair follicle (HF) and sebaceous gland (SG).
There are multiple stem cells in adult mammalian epidermis, but the mechanisms controlling lineage specification are poorly understood. To identify gene expression signatures of the three major epidermal differentiation compartments we micro-dissected individual SG, IFE and HF from adult epidermis. ...
ORGANISM(S): Mus musculus 
2017-05-16 | E-GEOD-62604 | biostudies-arrayexpress
TranscriptomicsEpidermal overexpression of ∆NLef1 leads to deregulation of epidermal stem cell fate.
In adult K14ΔNLef1 mouse, the overexpression of ∆NLef1, a B-catenin dominat negative, in basal keratinocytes leads to the conversion of hair follicles into multilayered epithelial cysts and ectopic sebaceous gland. To uncover in vivo changes in gene expression associated to ∆NLef1 activity, we ...
ORGANISM(S): Mus musculus 
2017-05-16 | E-GEOD-62603 | biostudies-arrayexpress
UnknownUse of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study.
Not available
S-EPMC7446618 | biostudies-literature
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