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MLL encodes a histone methyltransferase that is critical in maintaining gene expression during embryonic development and hematopoiesis. 11q23 translocations encode chimeric MLL fusions that act as potent drivers of acute leukemia. However, it remains unclear what portion of the leukemic genome is un...
ORGANISM(S): Mus musculus 
These findings establish a modular and hierarchical framework for archaeal RNAP assembly, uncover key regulatory checkpoints, and demonstrate the essential role of small subunit stoichiometry. Given the shared subcomplex architecture and assembly logic, these insights not only fill a longstanding kn...
ORGANISM(S): Methanococcus Maripaludis X1 
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