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ProteomicsChaperonic function of a C/D snoRNA dictates the structure and function of translating ribosomes
Leishmania cause cutaneous and visceral diseases affecting millions worldwide. The parasite cycle between insect and mammalian hosts. In this study, we determined the landscape of this 2’-O- methylation (Nm) modification on the rRNA and found that two positions change during cycling between its two ...
ORGANISM(S): Leishmania major strain Friedlin 
2026-06-02 | PXD052150 | Pride
Cryo-em Ribosome Chaperon Snorna Translation 
ProteomicsRole of H/ACA snoRNA in translation
Trypanosomes are unicellular parasites that cycle between the insect and mammalian host and is the causative agent of African sleeping sickness and the wasting disease, nagana, in cattle. Previous studies from our lab suggested that individual rRNA modification such as pseudouridine (Y) and 2’-O-m...
ORGANISM(S): Trypanosoma brucei 
2024-01-26 | PXD030544 | Pride
Pseudouridine Rna modification Snorna Quantitative proteomics Trypanosome 
ProteomicsDual functionality of a small nucleolar RNA dictates the structure and function of translating ribosomes
Leishmania causes cutaneous and visceral diseases affecting millions of patients worldwide. The parasite cycles between two different hosts, insect and mammalian. In this study, we determined the landscape of 2’-O- methylation (Nm) modification on Leishmania rRNA, and found two Nm positions that are...
ORGANISM(S): Leishmania major strain Friedlin 
2026-06-02 | PXD068423 | Pride
Cryo-em Leishmania 2’-o-methylation Ribosome structure Rna chaperone C/d snorna 
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