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A mouse model of HCC has been developed based on the reported inactivation of the RB pathway in the majority of human HCC. This mouse model harbors floxed alleles of Rb and p130 genes, as well as germline mutation of the p107 gene. Various strategies to activate the activity of a Cre recombinase lea...
ORGANISM(S): Mus musculus 
The goal of this experiment is to determine cell surface markers that are present in human beta cells or alpha cells but not both. Cells from human islets were FACS sorted and prepared as matched pairs of beta and alpha cells preparations.
ORGANISM(S): Homo sapiens 
The goal of this experiment is to identify genes differentially expressed in FACS-sorted Alpha and Beta cells.
ORGANISM(S): Homo sapiens 
The goal of this experiment is to identify genes differentially expressed in representative pancreatic FACS-sorted cell types.
ORGANISM(S): Homo sapiens 
Insulin-secreting β cells and glucagon-secreting α cells maintain physiological blood glucose levels, and their malfunction drives diabetes development. Using ChIP sequencing and RNA sequencing analysis, we determined the epigenetic and transcriptional landscape of human pancreatic α, β, and exocrin...
ORGANISM(S): Homo sapiens 
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