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TranscriptomicsThe star-nosed mole reveals clues to the molecular basis of mammalian touch.
Little is known about the molecular mechanisms underlying mammalian touch transduction. To identify novel candidate transducers, we examined the molecular and cellular basis of touch in one of the most sensitive tactile organs in the animal kingdom, the star of the star-nosed mole. Our findings demo...
ORGANISM(S): Mus musculus 
2013-05-31 | E-GEOD-47480 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of murine neurons in the nodose and dorsal root ganglia to elucidate molecular characteristics of different sensory neorons.
Vagal afferent neurons are thought to convey primarily physiological information, whereas spinal afferents transmit noxious signals from the viscera to the central nervous system. In order to elucidate molecular identities for these different properties, we compared gene expression profiles of neu...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2917 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of diabetic neuropathy in dorsal root ganglia from streptozotocin-diabetic male wistar rats over the first 8 weeks of diabetes
A study of diabetic neuropathy in dorsal root ganglia from streptozotocin-diabetic male wistar rats over the first 8 weeks of diabetes
ORGANISM(S): Rattus norvegicus 
2006-12-10 | E-MEXP-515 | biostudies-arrayexpress
MetabolomicsMicrobial-derived Hyodeoxycholic Acid Ameliorates Painful Diabetic Neuropathy by Modulating Dorsal Root Ganglion TLR4-Mediated Neuroinflammation Signaling Pathway

BACKGROUND: Painful diabetic neuropathy (PDN) is characterized by hyperalgesia and neuronal hyperexcitability. Although gut microbiota dysbiosis have been found in PDN, how microbiota influences PDN remains largely unexplored. RESULTS: Gut microbiota and its metabolites impacted PDN was investiga...

2026-08-24 | MTBLS12087 | MetaboLights
ProteomicsIntegrative multiomic analyses of dorsal root ganglia in diabetic neuropathic pain using proteomics, phosphoproteomics, and metabolomics
Diabetic peripheral neuropathy (DPN) is characterized by spontaneous pain in the extremities. Incidence of DPN continues to rise with the global diabetes epidemic. However, there remains a lack of safe, effective analgesics to control this chronic painful condition. Dorsal root ganglia (DRG) contain...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-09 | MSV000091027 | MassIVE
TranscriptomicsTranscriptional profiling of BXD dorsal root ganglia
We sequenced dorsal root ganglia mRNA from 25 BXD recombinant inbred mouse strains to determine their variation in gene expression. Dorsal root ganglia mRNA profiles of recombinant inbred mouse strains
ORGANISM(S): Mus musculus 
2015-06-11 | E-GEOD-69374 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome analysis of FACS purified somatosensory neuron subtypes and whole dorsal root ganglia tissue
The goal of this study was to analyze global gene expression in specific populations of somatosensory neurons in the periphery, including major, non-overlapping populations that include nociceptors, pruriceptors, and prorioceptors. The mammalian somatosensory nervous system encodes the perception of...
ORGANISM(S): Mus musculus 
2014-12-23 | E-GEOD-55114 | biostudies-arrayexpress
ProteomicsDorsal root ganglia(DRG) proteomic analysis
Complete annotation mice dorsal root ganglia proteome
ORGANISM(S): Mus musculus (Mouse) 
2023-05-09 | PXD041382 | Pride
Dorsal root ganglia 
ProteomicsProteomic profile of (Laser-dissected) Motoneurons, Ependymal Cells and Dorsal Root Ganglia Cells, and after Spinal Cord Injury in Rat
Spinal cord injury triggers extensive molecular remodeling in neural and glial compartments. To resolve these processes at cell-type-specific resolution, we performed quantitative proteomic profiling of laser-microdissected motor neurons (MNs), dorsal root ganglia (DRG), and ependymal cells (EC) fro...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-03-13 | PXD070428 | Pride
Motorneurons Dorsal root ganglia Spinal cord injury Laser microdissection Tmt-based proteomics 
TranscriptomicsTranscription profiling of Xenopus dorsal root ganglia conditioned in vitro vs freshly dissected control
Axonal regeneration is enhanced by prior conditioning peripheral nerve lesions. Here we show that Xenopus dorsal root ganglia (DRGs) with attached peripheral nerves (PN-DRGs) can be conditioned in vitro, thereafter showing enhanced axonal growth in response to neurotrophins, similar to preparations...
ORGANISM(S): Xenopus laevis 
2008-04-16 | E-MEXP-1297 | biostudies-arrayexpress
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