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TranscriptomicsTranscription profiling of human A549 cell line activated with either cyclic stretch (20% elongation), tumor necrosis factor or lipopolysaccharide
Alveolar epithalial cells (A549) were used as a model of pulmonary parenchymal cell activation to quiery gene expression profile of activation with either cyclic stretch (20% elongation), TNF (20 ng/ml), LPS (1 mcg/ml) or TNF+STRETCH at both 1 and 4 hrs.
ORGANISM(S): Homo sapiens 
2007-08-04 | E-GEOD-1541 | biostudies-arrayexpress
TranscriptomicsMesenchymal Stem Cells Reduce Inflammation while Enhancing Bacterial Clearance and Improving Survival in Sepsis
Expression data from Total RNA extracted from murine spleen. Sepsis was induced in C57Bl/6J mice by cecal ligation and puncture (CLP), followed 6 hours later by an intravenous injection of Mesenchymal Stem Cell (MSC) or saline. Twenty-eight hours after CLP, plasma, bronchoalveolar lavage (BAL) flui...
ORGANISM(S): Mus musculus 
2010-11-22 | E-GEOD-24357 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis reveals abnormal repair and remodeling in survivors of critical illness with sustained muscle weakness
ICU acquired weakness (ICUAW) is a complication of critical illness characterized by structural and functional impairment of skeletal muscle that may persist for years after ICU discharge with many survivors developing protracted courses with few regaining functional independence. Elucidating molec...
ORGANISM(S): Homo sapiens 
2016-07-18 | E-GEOD-78929 | biostudies-arrayexpress
GenomicsHomo sapiens
Transcriptomic analysis reveals abnormal repair and remodeling in survivors of critical illness with sustained muscle weakness
PRJNA314449 | ENA
TranscriptomicsRole of mast cells in pulmonary hypertension with left heart disease
Left heart disease (LHD) frequently causes lung vascular remodelling and pulmonary hypertension (PH). Yet, pharmacological treatment for PH in LHD is lacking and its pathophysiological basis remains obscure. We aimed to identify candidate mechanisms of PH in LHD and to test their relevance and thera...
ORGANISM(S): Rattus norvegicus 
2016-07-22 | E-GEOD-84704 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bronchial epithelial cells exposed to cyclic stretch with and without LPS or TNFa
Acute respiratory distress syndrome (ARDS) is a catastrophic form of acute lung injury (ALI). The necessity for mechanical ventilation (MV) renders patients at risk for ventilator induced lung injury (VILI). Exposure to repetitive cyclic stretch (CS) and/or over-inflation exacerbates injury. Reducin...
ORGANISM(S): Homo sapiens 
2009-09-15 | E-GEOD-16650 | biostudies-arrayexpress
TranscriptomicsMesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis.
Expression data from Total RNA extracted from murine spleen, liver, lungs, kidneys and hearts. Sepsis was induced in C57Bl/6J mice by cecal ligation and puncture (CLP), followed 6 hours later by an intravenous injection of Mesenchymal Stem Cell (MSC) or saline. Twenty-eight hours after CLP, plasma,...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-40180 | biostudies-arrayexpress
UnknownPersistent SARS-COV-2 infection in vaccinated individual with three doses of COVID-19 vaccine.
Not available
S-EPMC9910026 | biostudies-literature
ProteomicsPhages ZC01 and ZC03 require Type-IV Pilus for Pseudomonas aeruginosa infection and have a potential for therapeutic applications
There has been a growing interest in bacteriophages as therapeutic agents to treat multidrug-resistant bacterial infections, particularly those caused by the ESKAPE group. The present work aimed at expanding the microbiological and molecular characterization of phages ZC01 and ZC03 and investigating...
ORGANISM(S): Pseudomonas aeruginosa PA14 
2025-05-07 | PXD055478 | Pride
Pseudomonas aeruginosa  pa14  phage therapy  phage receptor  type-4 pilus 
TranscriptomicsPolymicrobial sepsis-induced Myocardial Depression Transcriptional Profile
To describe the transcriptional changes associated with polymicrobial-sepsis induced myocardial depression in wild type and iNOS deficient mice. Keywords: myocardium, contractility, differential gene expression, nitric oxide synthase, infection We compared the transcriptional profile of C57/BL6 WT m...
ORGANISM(S): Mus musculus 
2010-11-17 | E-GEOD-9667 | biostudies-arrayexpress
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