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TranscriptomicsTrans-effects of chromosome aneuploidies on DNA methylation patterns: DNA methylation analysis of Down syndrome in human brain tissues and cells
Background: Trisomy 21 causes Down syndrome (DS), but the mechanisms by which the extra chromosome leads to deficient intellectual and immune function are not well understood. Results: Here, we profile CpG methylation in DS and control cerebral and cerebellar cortex of adults and cerebrum of fetuse...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-74486 | biostudies-arrayexpress
TranscriptomicsSingle cell genotyping of Myeloid Leukaemia of Down Syndrome cells
Single cells from ML-DS sample 186-2 (bone marrow) were analysed to determine whether mutations in JAK2 and CSF2RB ocurred in the same or different cells in this patient. Single live, CD19neg, CD3neg, CD45mid and CD117 positive cells were sorted into 96-well plates on the BD Fusion with antibodies ...
ORGANISM(S): Homo sapiens 
2020-12-31 | E-MTAB-7935 | biostudies-arrayexpress
TranscriptomicsRNA sequencing data from Myeloid Leukaemia of Down Syndrome (ML-DS)
Paired-end 150bp RNA sequencing data from ML-DS samples.
ORGANISM(S): Homo sapiens 
2020-12-31 | E-MTAB-7932 | biostudies-arrayexpress
GenomicsTrans-effects of sub-chromosomal duplications on DNA methylation patterns in mouse models of Down syndrome: whole genome bisulfite sequencing of cerebral samples from Dp(10)1Yey and Dp(16)1Yey mouse models.
Background: Trisomy 21 causes Down syndrome (DS), but the mechanisms by which the extra chromosome leads to deficient intellectual and immune function are not well understood. Results: Here, we profile CpG methylation in DS and control cerebral and cerebellar cortex of adults and cerebrum of fetuse...
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-74505 | biostudies-arrayexpress
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