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ProteomicsARID1A recruits non-homologous end joining factors to DNA breaks induced by G4 ligands
ARID1A is a subunit of the BAF chromatin remodelling complex that is frequently mutated in cancer. However, it is challenging to predict how ARID1A loss might impact on responses to cancer therapies because it participates in many different cellular pathways. G quadruplex (G4) binding ligands, such ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-15 | PXD063556 | Pride
G4 ligands Arid1a 
ProteomicsMulti-omic profiling following loss of SWI/SNF reveals global changes in cohesin binding and sensitivity to cohesin perturbation
SWI/SNF is a family of multi-subunit chromatin remodelling complexes comprised of BAF, PBAF and ncBAF. These complexes have diverse roles in cellular processes including transcription, replication, and repair, and play an important role in maintaining genome stability, with over 20% of all cancers h...
ORGANISM(S): Homo sapiens (Human) 
2026-02-20 | PXD065273 | Pride
Cohesin Swi/snf 
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