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MetabolomicsThe patatin-like protein PlpD forms novel structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane

Members of the Omp85 superfamily of outer membrane proteins (OMPs) found in Gram-negative bacteria, mitochondria and chloroplasts are characterized by a distinctive 16-stranded β-barrel transmembrane domain and at least one periplasmic POTRA domain. All previously studied Omp85 proteins promote c...

2025-12-08 | MTBLS9803 | MetaboLights
TranscriptomicsIntegrated nuclear proteomics and transcriptomics identifies new high frequency dysregulated targets in acute myeloid leukemia
Acute myeloid leukemia (AML) is characterized by developmental arrest which is thought to arise from transcriptional dysregulation of myeloid development programs. Here, we have analyzed the transcriptome of AML blasts in comparison with normal human CD34+ cells using the HTA 2.0 gene chip. We have ...
ORGANISM(S): Homo sapiens 
2019-10-02 | E-MTAB-3873 | biostudies-arrayexpress
TranscriptomicsInterferon lambda restricts West Nile virus neuroinvasion by enhancing integrity of the blood-brain barrier
Although type III interferons (IFN), also known as IFN-λ or IL28/IL-29, restrict infection by several viruses, their mechanism of inhibitory action has remained uncertain. We used recombinant IFN-λ and mice lacking the IFN-λ receptor (IFNLR1) to evaluate the effect of IFN-λ on infection with West Ni...
ORGANISM(S): Mus musculus 
2015-01-08 | E-GEOD-64735 | biostudies-arrayexpress
GenomicsInternational Multi-Center ADHD Gene Project (IMAGE) II Case Sample

This sample represents a collection of cases across a range of sites. All of these samples were ascertained for ADHD with most meeting criteria for combined type ADHD. The collection sites span Europe and America. Further details on the source and inclusion and exclusion information can be found ...

phs000407.v1.p1 | EGA
GenomicsThe PUWMa (Pfizer-funded study from the University of California Los Angeles (UCLA), Washington University (WASH-U), and Massachusetts General Hospital (MGH)) GWAS of ADHD

The PUWMa GWAS of ADHD is a multi-site collaboration initiated to conduct a family-based association study from existing research samples. The source sample of ADHD families was ascertained at Massachusetts General Hospital (MGH, N=309 trios), Washington University at St. Louis (WASH-U, N...

phs000358.v1.p1 | EGA
UnknownThe REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial.
Not available
S-EPMC5838871 | biostudies-literature
UnknownMicrobial Translocation Does Not Drive Immune Activation in Ugandan Children Infected With HIV.
Not available
S-EPMC6284549 | biostudies-literature
UnknownEffects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial.
Not available
S-EPMC6617509 | biostudies-literature
UnknownEffects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial.
Not available
S-EPMC7645733 | biostudies-literature
UnknownEffects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage: Extended Follow-up of the RESTART Randomized Clinical Trial.
Not available
S-EPMC8417806 | biostudies-literature
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