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GenomicsRNA seq of HEK293 treated with Blebbistatin or expressing C9orf72 associated Di Peptide Repeats (DPRs)
RNA seq of HEK293 treated with Blebbistatin or expressing C9orf72 associated Di Peptide Repeats (DPRs)
PRJEB65357 | ENA
TranscriptomicsRNA seq of HEK293 treated with Blebbistatin or expressing C9orf72 associated Di Peptide Repeats (DPRs)
To identify if the alteration of Myosin activity identified in DPRs expressing cells induced alterations in the transcriptome profile of cells. For that purpose, we compared the changes in HEK293 cells transcriptome induced by a known myosin activity disruptor, Blebbistatin, with DPRs expressing cel...
ORGANISM(S): Homo sapiens 
2023-10-09 | E-MTAB-13292 | biostudies-arrayexpress
UnknownC9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons.
Not available
S-EPMC9108631 | biostudies-literature
UnknownCombinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila.
Not available
S-EPMC6107282 | biostudies-literature
UnknownNeuronal Wiring Receptors Dprs and DIPs Are GPI Anchored and This Modification Contributes to Their Cell Surface Organization.
Not available
S-EPMC10863630 | biostudies-literature
ProteomicsDenitrifying phosphorus removal sludge with heavy metals
DPRS treated by Cd2+, Ni2+ and Cr6+. We look into the differences in metaproteome of treated reactors and the control group, and aim to find the resistance mechanisms of DPRS toward heavy metals
ORGANISM(S): Acidobacteriaceae Bacterium A2-4c Escherichia Coli 
2020-06-10 | PXD019707 |
ProteomicsArginine valency in C9ORF72 dipolypeptides mediates promiscuous proteome binding that transmits multiple modes of toxicity
Motor Neuron Disease patients with the C9ORF72 hexanucleotide expansion mutations feature abnormal expression of 5 different dipeptide repeat polymers (DPRs). Two of these, poly-GR and poly-PR, have proven highly toxic to cell and animal models. To investigate the mechanisms, we defined the interact...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-25 | PXD015177 | Pride
Ran-translation  amyotrophic lateral sclerosis (als)  proteotoxicity  protein aggregation  abce1  methylosome  prmt1  prmt5 
TranscriptomicsDual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo
The most common genetic cause of both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is a G4C2 repeat expansion in intron 1 of the C9orf72 gene. This repeat expansion undergoes bidirectional transcription to produce sense and antisense repeat RNA species. Both sense and antise...
ORGANISM(S): Homo sapiens 
2024-11-15 | GSE255022 | GEO
ProteomicsC9orf72 arginine-rich dipeptide repeat proteins disrupt importin beta-mediated nuclear import
Disruption of nucleocytoplasmic transport (NCT), including mislocalization of the importin beta cargo, TDP-43, is a hallmark of amyotrophic lateral sclerosis (ALS), including ALS caused by a hexanucleotide repeat expansion in C9orf72. However, the mechanism(s) remain unclear. Importin beta and its c...
ORGANISM(S): Homo sapiens (Human) 
2020-05-20 | PXD015656 | Pride
Importin beta Nuclear transport Amyotrophic lateral sclerosis C9orf72 
ProteomicsInteractome of C9orf72 arginine-rich dipeptide proteins
A GGG GCC hexanucleotide repeat expansion within the C9orf72 gene is the most common genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia. Sense and antisense repeat-containing transcripts undergo repeat associated non-AUG-initiated translation to produce five dipeptide pr...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-01-07 | PXD012099 | Pride
Ap-ms Brain Orbitrap Drosophila Lc-ms/ms 
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