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ProteomicsCGG repeat RNA binding protein capture identifies SRSF protein kinase 1 as a modulator of RAN translation and suppressor of repeat toxicity
Transcribed CGG repeat expansions cause the neurodegenerative disorder Fragile X-associated tremor/ataxia syndrome (FXTAS). CGG repeat RNAs sequester RNA-binding proteins (RBPs) into nuclear foci and undergo repeat-associated non-AUG (RAN) translation into toxic peptides in the cytoplasm. To identif...
ORGANISM(S): Homo sapiens (Human) 
2021-09-28 | PXD027000 | Pride
Ran translation Repeat rna 
GenomicsMechanistic insights into RAN translation within the Huntingtin coding sequence
Mechanistic insights into RAN translation within the Huntingtin coding sequence
PRJNA1463861 | ENA
TranscriptomicsMechanistic insights into RAN translation within the Huntingtin coding sequence
Nucleotide repeat expansions support the production of toxic peptides from putatively non-coding regions of the human genome in the absence of an AUG initiation codon. This process, known as repeat-associated non-AUG (RAN) translation, was originally described at CAG repeat expansions with products ...
ORGANISM(S): Homo sapiens 
2026-05-13 | GSE330454 | GEO
GenomicsSynergy between CGG Repeat RNA and RAN translation drives FXTAS pathogenesis through Protein Kinase R
Synergy between CGG Repeat RNA and RAN translation drives FXTAS pathogenesis through Protein Kinase R
PRJNA1529061 | ENA
UnknownRAN Translation in Huntington Disease.
Not available
S-EPMC4684947 | biostudies-literature
TranscriptomicsSynergy between CGG Repeat RNA and RAN translation drives FXTAS pathogenesis through Protein Kinase R
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by transcribed CGG repeat expansions in the 5′ untranslated region of FMR1. Both CGG repeat RNA and repeat-associated non-AUG (RAN) translation of the polyglycine-containing protein FMRpolyG are imp...
ORGANISM(S): Mus musculus 
2026-09-16 | GSE347172 | GEO
UnknownMapping of repeat-associated non-AUG (RAN) translation knowledge: A bibliometric analysis.
Not available
S-EPMC11019168 | biostudies-literature
UnknownRepeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy.
Not available
S-EPMC5886103 | biostudies-literature
UnknownSRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity.
Not available
S-EPMC8573603 | biostudies-literature
UnknownNeuropathology of RAN translation proteins in fragile X-associated tremor/ataxia syndrome.
Not available
S-EPMC6821001 | biostudies-literature
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