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ProteomicsLongitudinal Drain-Fluid Proteomics Reveals Procedure-Specific Signatures of Postoperative Leakage after Pancreatic and Colorectal Surgery
Anastomotic leakage is a major complication after gastrointestinal surgery, yet early detection remains limited by nonspecific clinical signs and narrow biomarker panels. Here, we used longitudinal data-independent acquisition proteomics to profile postoperative drain fluid from two surgical cohorts...
ORGANISM(S): Homo sapiens (Human) 
2026-09-08 | PXD082236 | Pride
Anastomotic leakage Lc-ms based proteomics Drain-fluid Pancreatic and colorectal surgery Longitudinal profiling 
ProteomicsLongitudinal Drain-Fluid Proteomics Reveals Procedure-Specific Signatures of Postoperative Leakage after Pancreatic and Colorectal Surgery
Anastomotic leakage is a major complication after gastrointestinal surgery, yet early detection remains limited by nonspecific clinical signs and narrow biomarker panels. Here, we used longitudinal data-independent acquisition proteomics to profile postoperative drain fluid from two surgical cohorts...
ORGANISM(S): Homo sapiens (Human) 
2026-09-08 | PXD082170 | Pride
Anastomotic leakage Lc-ms based proteomics Drain-fluid Pancreatic and colorectal surgery Longitudinal profiling 
ClinicalDrain Fluid Amylase as an early biomarker of anastomotic leak in low colorectal anastomoses
Interventions: Measure amylase levels in drain fluid daily after low colorectal anastomoses as an early indicator of anastomotic leak. - a small sample of drain fluid will be collected daily while pelvic drain is in situ during hospital admission following colorectal surgery and samples will be sen...
2471651 | ecrin-mdr-crc
UnknownWide variation in tissue, systemic, and drain fluid exposure after oxaliplatin-based HIPEC: results of the GUTOX study.
Not available
S-EPMC7338818 | biostudies-literature
UnknownEarly postoperative drain fluid amylase in risk-stratified patients promotes tailored post-pancreatectomy drain management and potential for accelerated discharge.
Not available
S-EPMC7288221 | biostudies-literature
UnknownAssessing Intra-abdominal status for clinically relevant postoperative pancreatic fistula based on postoperative fluid collection and drain amylase levels after distal pancreatectomy.
Not available
S-EPMC10914692 | biostudies-literature
UnknownThe value of serum amylase and drain fluid amylase to predict postoperative pancreatic fistula after pancreatoduodenectomy: a retrospective cohort study.
Not available
S-EPMC8578085 | biostudies-literature
UnknownDrain fluid iodine as a biomarker of anastomotic leak after low anterior resection in patients undergoing Gastrografin rectal tube flushes and omission of a diverting ileostomy: The GUSH study.
Not available
S-EPMC11840294 | biostudies-literature
UnknownEffectiveness of Lumbar Cerebrospinal Fluid Drain Among Patients With Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial.
Not available
S-EPMC10277935 | biostudies-literature
UnknownWhich is the best predictor of clinically relevant pancreatic fistula after pancreatectomy: drain fluid concentration or total amount of amylase?
Not available
S-EPMC8560612 | biostudies-literature
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