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TranscriptomicsEpigenetic regulation of Bmp2 and Smad6 in Ras-induced senescence
Epigenetically silenced Ink4a-Arf locus is activated by loss of H3K27me3 in cellular senescence, where secreted factor expression is also involved. Here we analyzed epigenome and transcriptome alteration during Ras-induced senescence using mouse embryonic fibroblast (MEF). Seventeen genes with H3K27...
ORGANISM(S): Mus musculus 
2011-12-22 | E-GEOD-18125 | biostudies-arrayexpress
GenomicsTumor suppressor role of Ezh2 in an NRASQ61K driven model of Early T-cell Precursor Acute Lymphoblastic Leukemia (ChIP-Seq)
Purpose: To characterize changes in genome-wide H3K27me3 associated with homozygous inactivation the Polycomb Repressive Complex 2 (PRC2) lysine methyltransferase Ezh2 in a mouse model of earlt T-cell precursor ALL (ETP-ALL) Methods: We performed Chip-seq for the H3K27me3 Chromatin mark on Ezh2ff an...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-76601 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling by microarray of Caenorhabditis elegans MT2124 x CB4856 RILs used for eQTL mapping
We crossed the MT2124 strain carrying the let-60 (n1046) gain of function mutation with the wild-type strain CB4856. From this cross a panel of mutation introgression recombinant inbred lines (miRILs) was generated. Using this population, the influence of genetic variation on the the let-60 (gf) mut...
ORGANISM(S): Caenorhabditis elegans 
2017-07-21 | E-MTAB-5856 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse transgenic tumors driven by Her or Ras
previously published mouse data; Pubmed IDS: 12754511, 12839964 Experiment Overall Design: see Black, EP, et.al., Cancer Res. 2003 Jul 1;63(13):3716-23 and Huang, E., et.al. Nat Genet. 2003 Jun;34(2):226-30.
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3158 | biostudies-arrayexpress
TranscriptomicsReceptor Tyrosine Kinase pathway activation is sufficient to trigger chordoma in zebrafish
Oncogenic transformation of individual cell fates by developmental signaling cascades and transcription factors triggers diverse cancer types. Chordoma is a rare, aggressive tumor arising from transformed notochord remnants. Various potentially oncogenic factors have been found deregulated in chordo...
ORGANISM(S): Danio rerio 
2018-12-01 | E-MTAB-7349 | biostudies-arrayexpress
TranscriptomicsSystems analysis of adaptive responses to MAP Kinase pathway blockade in BRAF mutant melanoma.
Fifty percent of cutaneous melanomas are driven by activated BRAFV600E, but tumors treated with RAF inhibitors, even when they respond dramatically, rapidly adapt and develop resistance. Thus, there is a pressing need to identify the major mechanisms of intrinsic and adaptive resistance and develop ...
ORGANISM(S): Homo sapiens 
2015-09-16 | E-GEOD-68453 | biostudies-arrayexpress
TranscriptomicsHuman embryos commonly form abnormal nuclei during development: a mechanism of DNA damage, embryonic aneuploidy, and developmental arrest
Nuclear abnormalities are commonly found in human IVF embryos and are associated with DNA damage, aneuploidy, and decreased developmental potential. Immunohistochemical, microscopic, and cytogenetic analysis of human IVF embryos at different developmental stages and morphologic grades.
ORGANISM(S): Homo sapiens 
2015-09-11 | E-GEOD-72150 | biostudies-arrayexpress
TranscriptomicsA Pathobiological Role of the Insulin Receptor in CLL.
Purpose: The chromosomal deletion 11q affects biology and clinical outcome in CLL but del11q-deregulated genes remain incompletely characterized. Results: We have identified differential expression of the insulin receptor (INSR) in CLL, including high-level INSR expression in the majority of CLL wi...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-26526 | biostudies-arrayexpress
GenomicsHigh-throughput Detection of Clinically Relevant Mutations in Archived Tumor Samples By Multiplexed PCR and Next Generation Sequencing
PURPOSE: Tailoring cancer treatment to tumor molecular characteristics promises to make personalized medicine a reality. However, reliable genetic profiling of archived clinical specimens has been hindered by limited sensitivity and high false positive rates. Here, we describe a novel methodology, M...
EGAS00001000674 | EGA
GenomicsGenome-Wide Analysis of Hypodiploid Acute Lymphoblastic Leukemia

Hypodiploid acute lymphoblastic leukemia (ALL) is an aggressive form of leukemia characterized by multiple whole chromosomal losses and very poor outcome. Here we report an integrative genomic analysis that identifies multiple subtypes of hypodiploid ALL characterized by variation in the degree o...

phs000341.v1.p1 | EGA
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