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TranscriptomicsGenome wide mapping of effects of U6atac knockdown on pre-mRNA splicing
This project looks into experimentally identifying all minor introns by knocking down the minor spliceosome's catalytic snRNP, U6atac. Knockdown of U6atac by antisense morpholino followed by examining mRNA splicing by RNA-seq
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-48263 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of snRNAs bound to Gemin5 upon protein synthesis inhibition
Here, we report the genome-wide analysis of snRNAs that are bound to Gemin5 upon protein synthesis inhibition. Upon protein synthesis inhibition, the SMN complex that has a crucial role in the biogenesis of snRNPs dissociates into its subunits, leaving Gemin5 alone. The existence of these subunits w...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20751 | biostudies-arrayexpress
TranscriptomicsRNA-seq transcriptome profiling of motor neurons (MNs) and surrounding white matter glia (WM) microdissected from pre-symptomatic mouse model of spinal muscular atrophy (SMA)
We report tramscriptome perturbations in MNs and WM of SMA mouse, prior to first morphological and biochemical synaptic defects Examination of ventral horn MNs and WM isolated from lumbar segment spinal cords from wild type (WT) and SMA mice
ORGANISM(S): Mus musculus 
2013-11-05 | E-GEOD-51735 | biostudies-arrayexpress
TranscriptomicsEffects of Ars2 or DGCR8 siRNA on microRNA expression
Ars2 is a component of the nuclear cap-binding complex that is required for cellular proliferation and contributes to microRNA biogenesis. Arrays were performed to determine the repertoire of microRNAs that change following knock-down of Ars2. Knock-down of DGCR8 was also performed to determine whi...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-34680 | biostudies-arrayexpress
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