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MetabolomicsActivated ATF6α is a hepatic tumor driver restricting immunosurveillance

Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality with limited therapies. While endoplasmic reticulum (ER)-stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR-transducer activating transcription factor 6 alpha (ATF...

2025-11-17 | MTBLS13241 | MetaboLights
MetabolomicsImpaired Glycolysis-Derived Serine Metabolism as a Key Driver of Podocyte Injury with Senescence

Chronic kidney disease (CKD) is a major health issue, with podocyte injury with senescence playing a central role in glomerulosclerosis. This study investigates the link between glycolysis-derived serine metabolism and podocyte injury with senescence, focusing on the role of phosphoglycerate kina...

2025-08-23 | MTBLS12883 | MetaboLights
TranscriptomicsFrequent driver mutations in histone H3.3 and chromatin remodeling genes in paediatric glioblastoma
Whole exome sequencing identified frequent driver mutations in a series of paediatric glioblastomas We used microarray-based profiling to investigate differences in gene expression according to mutational status of driver genes RNA from 27 primary tumor samples was subject to QC by Agilent BioAnalys...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-34824 | biostudies-arrayexpress
MetabolomicsDefective cytokinin signaling reprograms lipid and flavonoid gene-to-metabolite networks to mitigate high salinity in Arabidopsis

Cytokinin (CK) in plants regulates both developmental processes and adaptation to environmental stress. Arabidopsis histidine phosphotransfer ahp2,3,5 and type-B response regulator arr1,10,12 triple mutants are almost completely defective in CK signaling, and the ahp2,3,5

2021-11-25 | MTBLS2532 | MetaboLights
GenomicsGene expression profile of EGFRwt/KRASwt/ALKwt lung adenocarcinoma (“pan-driver-gene-negative” LUAD) and developing a prognostic signature for “pan-driver-gene-negative” LUAD
Gene expression profile of EGFRwt/KRASwt/ALKwt lung adenocarcinoma (“pan-driver-gene-negative” LUAD) and developing a prognostic signature for “pan-driver-gene-negative” LUAD
PRJNA473511 | ENA
ProteomicsLarge-scale multi-omic analysis identifies noncoding somatic driver mutations and nominates ZFP36L2 as a driver gene for pancreatic ductal adenocarcinoma
Background The identification and characterization of somatic cancer driver mutations in the noncoding genome remains challenging. Objective To broadly characterize noncoding driver mutations for pancreatic ductal adenocarcinoma (PDAC). Design Using mutation calls from whole-genome sequence (WGS) ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-07-23 | MSV000098624 | MassIVE
TranscriptomicsCandidate driver genes in focal chromosomal aberrations of stage II colon cancer
Chromosomal instable colorectal cancer is marked by specific large chromosomal copy number aberrations. Recently, focal aberrations of 3Mb or smaller have been identified as a common phenomenon in cancer. Inherent to their limited size, these aberrations harbour one or few genes. The aim of this stu...
ORGANISM(S): Homo sapiens 
2010-04-19 | E-GEOD-17047 | biostudies-arrayexpress
GenomicsMetastatic site influences driver gene function in pancreatic cancer [scMultiome]
Metastatic site influences driver gene function in pancreatic cancer [scMultiome]
PRJNA1030031 | ENA
UnknownIMI-driver: Integrating multi-level gene networks and multi-omics for cancer driver gene identification.
Not available
S-EPMC11379397 | biostudies-literature
GenomicsMetastatic site influences driver gene function in pancreatic cancer [scRNA-seq]
Metastatic site influences driver gene function in pancreatic cancer [scRNA-seq]
PRJNA1262412 | ENA
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