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MetabolomicsMetabolic analysis of wound response in Wolbachia infected Drosophila melanogaster

Viral studies of Drosophila melanogaster typically involve virus injection with a small needle, causing post-injury a wounding/wound healing response, in addition to the effects of viral infection. However, the metabolic response to the needle injury is understudied, and many viral investigations...

2025-11-18 | MTBLS13248 | MetaboLights
TranscriptomicsTranscription profiling of Drosophila infected with Drosophila C virus reveals a third evolutionary conserved innate immunity pathway operates in drosophila and counters viral infection
The response of drosophila to bacterial and fungal infections involves two signaling pathways, Toll and Imd, which both activate NF-kB family members. We have studied the global transcriptional response of flies to infection with drosophila C virus. Viral infection induced a set of genes distinct fr...
ORGANISM(S): Drosophila melanogaster 
2007-07-07 | E-GEOD-2828 | biostudies-arrayexpress
TranscriptomicsA Dicistrovirus-specific inducible antiviral response in Drosophila
The fruit fly Drosophila melanogaster is a good model to unravel the molecular mechanisms of innate immunity, and has led to some important discoveries on the sensing and signalling of microbial infections. The response of drosophila to virus infections remains poorly characterized, and appears to i...
ORGANISM(S): Drosophila melanogaster 
2013-02-06 | E-GEOD-31542 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of Drosophila cells to FHV infection (infection experiment)
Virus infections induce cellular gene up and down regulation, and these changes often provide clues to cellular pathways utilized by viruses. We used microarrays to examine the transcriptional responses of cultured Drosophila S2 cells to infection with Flock House virus (FHV). Experiment Overall Des...
ORGANISM(S): Drosophila melanogaster 
2009-04-11 | E-GEOD-15466 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila cells to FHV RNA1 replicon expression (replicon experiment)
Virus infections induce cellular gene up and down regulation, and these changes often provide clues to cellular pathways utilized by viruses. We used microarrays to examine the transcriptional responses of cultured Drosophila S2 cells to Flock House virus (FHV) replicon induction. Experiment Overall...
ORGANISM(S): Drosophila melanogaster 
2009-04-11 | E-GEOD-15467 | biostudies-arrayexpress
GenomicsProtein/DNA in vitro Binding seq (PB-seq) for Drosophila HSF and genomic Drosophila DNA
DNA sequence and local chromatin landscape act jointly to determine transcription factor (TF) binding intensity profiles. To disentangle these influences, we developed an experimental approach, called protein/DNA binding and high-throughput sequencing (PB-seq), that allows the binding energy landsca...
ORGANISM(S): Drosophila melanogaster 
2012-02-06 | E-GEOD-32570 | biostudies-arrayexpress
GenomicsDrosophila C virus strain:EB
Drosophila C virus isolate:EB Genome sequencing
PRJNA782868 | ENA
TranscriptomicsFunctional Specialization of the Small Interfering RNA Pathway in Response to Virus Infection
In Drosophila, the siRNA pathway is initiated when exogenous or endogenous double stranded RNA (dsRNA) is processed into siRNAs by Dicer-2 (Dcr-2) and a dsRNA-binding protein (dsRBP) cofactor called Loquacious (Loqs). The siRNAs are then loaded onto Argonaute-2 (Ago2) protein by the action of Dcr-2 ...
ORGANISM(S): Drosophila melanogaster 
2012-03-16 | E-GEOD-36449 | biostudies-arrayexpress
TranscriptomicsExpression profile of adult Drosophila melanogaster expressing a self-replicating RNA of Sindbis virus
Alphaviruses establish a persistent infection in arthropod vectors, which is essential for effective transmission of the virus to vertebrate hosts. The development of persistence in insects is not well understood, although it is thought to involve the innate immune response. Using a transgenic fly s...
ORGANISM(S): Drosophila melanogaster 
2013-01-31 | E-GEOD-42726 | biostudies-arrayexpress
TranscriptomicsHierarchical rules for Argonaute loading in Drosophila
Drosophila Argonaute-1 and Argonaute-2 differ in function and small RNA content. AGO2 binds to siRNAs, whereas AGO1 is almost exclusively occupied by microRNAs. microRNA duplexes are intrinsically asymmetric, with one strand, the miR strand, preferentially entering AGO1 to recognize and regulate the...
ORGANISM(S): Drosophila melanogaster 
2009-11-15 | E-GEOD-17734 | biostudies-arrayexpress
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