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Human H1299 lung cancer cells or clones engineered for tetracycline-inducible expression of wild type IRP2, or the deletion mutant IRP2?73 (lacking a specific insert of 73 amino acids), were injected subcutaneously into nude mice. The induction of IRP2 profoundly stimulated the growth of tumor xenog...
ORGANISM(S): Homo sapiens 
Antral gastrin, secreted by G-cells, is a key regulator of gastric acid secretion. We developed a pure G-cell system to identify the mechanistic basis of gastrin regulation. Rat G-cells were prepared by Nycodenz gradient centrifugation and FACS-sorting. G-cells secretion was assessed utilizing neura...
ORGANISM(S): Rattus norvegicus 
Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell activity during inflammation remains unclear. Here we show, using chimeric mice, cell depletion and adoptive cell transfer...
ORGANISM(S): Mus musculus 
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