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MetabolomicsMolecular networking coupled to high-resolution mass spectrometry fragmentation reveals a multitude of urinary antihypertensive drug metabolites
Mass spectrometry is the current technique of choice in studying drug metabolism. High-resolution mass spectrometry (HR-MS) in combination with fragment analysis (MS/MS) has the potential to contribute to rapid advances in this field. However, the data emerging from such fragmentation spectra pose c...
2016-05-23 | MTBLS307 | MetaboLights
MetabolomicsSerum Predose Metabolic Profiling For Prediction Of Rosuvastatin Pharmacokinetic Parameters In Healthy Volunteers
Rosuvastatin is a quite known lipid-lowering agent generally used for hypercholesterolemia treatment and coronary artery diseases prevention. There is substantial inter-individual variability in the absorption of statins usually caused by genetic polymorphisms leading to variation in the correspondi...
2021-10-29 | MTBLS3128 | MetaboLights
Genomicsin silico drug target prediction for melanoma
The in silico single gene deletion step was adapted to simulate the knock-out of all targets of a drug on an objective function such as growth or energy balance. Based on publicly available and in-house large scale transcriptomic data, metabolic models for melanoma were reconstructed, enabling the p...
EGAS00001006463 | EGA
GenomicsA Deep Learning based Efficacy Prediction System for Drug Discovery [Perillen]
A Deep Learning based Efficacy Prediction System for Drug Discovery [Perillen]
PRJNA693496 | ENA
GenomicsA Deep Learning based Efficacy Prediction System for Drug Discovery [Trametinib]
A Deep Learning based Efficacy Prediction System for Drug Discovery [Trametinib]
PRJNA693497 | ENA
GenomicsA Deep Learning based Efficacy Prediction System for Drug Discovery [Chikusetsusaponin IV]
A Deep Learning based Efficacy Prediction System for Drug Discovery [Chikusetsusaponin IV]
PRJNA693494 | ENA
GenomicsA Deep Learning based Efficacy Prediction System for Drug Discovery
A Deep Learning based Efficacy Prediction System for Drug Discovery
PRJNA693487 | ENA
TranscriptomicsA Deep Learning based Efficacy Prediction System for Drug Discovery [Trametinib]
Target protein-based drug and research compound discovery has been undeniably successful strategy in life science research, yet many diseases and biological processes lack obvious targets to enable these approaches. Here, to overcome this major challenge we have developed a deep-learning based effic...
ORGANISM(S): Mus musculus 
2023-03-31 | GSE165174 | GEO
TranscriptomicsA Deep Learning based Efficacy Prediction System for Drug Discovery [Perillen]
Target protein-based drug and research compound discovery has been undeniably successful strategy in life science research, yet many diseases and biological processes lack obvious targets to enable these approaches. Here, to overcome this major challenge we have developed a deep-learning based effic...
ORGANISM(S): Mus musculus 
2023-03-31 | GSE165173 | GEO
TranscriptomicsGenome-wide tissue gene expression profiling in 1 year old Göttingen Minipigs with customized NimbleGen microarrays
Minipigs resemble many features of human anatomy, physiology, and biochemistry and represent an animal model for drug efficacy and safety testing. To evaluate at the molecular level the expression of drug targets, drug metabolism pathways or general features of organ transcriptomes in minipigs, we u...
ORGANISM(S): Sus scrofa 
2015-12-16 | E-GEOD-71438 | biostudies-arrayexpress
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