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MetabolomicsClinical Application Value of Ceramide and Sphingomyelin as Biomarkers for the Diagnosis of Drug-Induced Liver Injury

Background : Drug-induced liver injury (DILI) is a serious health concern that presents challenges in early detection and accurate diagnosis, thereby complicating the treatment of this liver disease. Therefore, it is crucial to explore specific biomarkers to improve the accuracy of diagnosing DIL...

2025-07-23 | MTBLS12765 | MetaboLights
MetabolomicsBioaccumulation of therapeutic drugs by human gut bacteria (B.animalis assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1264 | MetaboLights
MetabolomicsAssessing the Feasibility of In Vitro Assays in Combination with Biological Matrices to Screen for Endogenous CYP450 Phenotype Biomarkers Using an Untargeted Metabolomics Approach—A Proof of Concept Study

Cytochrome P450 (CYP) enzymes are crucial for drug metabolism, yet inter-individual variability in their activity remains a significant clinical challenge. Current phenotyping methods are often impractical or even impossible, particularly in forensic toxicology and vulnerable populations. This pr...

2025-12-12 | MTBLS13325 | MetaboLights
Transcriptomics293_hORF3.1_drug_treatments
Identification of human ORFs conferring resistance to various drug treatments when overexpressed into HEK293-M2, assessed by microarrays
ORGANISM(S): Homo sapiens 
2014-05-15 | E-MTAB-2493 | biostudies-arrayexpress
TranscriptomicsIn vivo screen of Francisella tularensis subsp. novicida mutants in sequence defined transposon library
We used an inhalation mouse model of infection to query a collection of 2149 mutants in a Francisella tularensis subsp. novicida background for genes required for growth, survival and systemic dissemination. A microarray-based genome-wide negative selection screen (Microarray tracking of transposon ...
ORGANISM(S): Francisella tularensis subsp. novicida 
2008-12-30 | E-GEOD-11297 | biostudies-arrayexpress
GenomicsN39 APOA1-tdTomato drug screen
N39 APOA1-tdTomato drug screen
PRJNA1142560 | ENA
GenomicsTargeted gene screen of drug resistant organoids
Sequencing of drug resistant organoids
EGAS00001001797 | EGA
TranscriptomicsRNA-seq analysis of vorinostat-resistant HCT116 cells following gene knockdown of GLI1 or PSMD13 with or without vorinostat treatment
Transcriptome analysis was conducted on vorinostat resistant HCT116 cells (HCT116-VR) upon knockdown of potential vorinostat resistance candidate genes in the presence and absence of vorinostat. Potential vorinostat resistance candidate genes chosen for this study were GLI1 and PSMD13, which were i...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-57871 | biostudies-arrayexpress
MetabolomicsBioaccumulation of therapeutic drugs by human gut bacteria: duloxetine accumulation at different concentrations (L.saccharolytica;E.coli assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1319 | MetaboLights
GenomicsMND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
CRISPR screen data
ORGANISM(S): Homo sapiens 
2023-05-31 | E-MTAB-12929 | biostudies-arrayexpress
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