Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Katrina Falkenberg
PROVIDER: E-GEOD-57871 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Falkenberg K J KJ Newbold A A Gould C M CM Luu J J Trapani J A JA Matthews G M GM Simpson K J KJ Johnstone R W RW
Cell death and differentiation 20160212 7
Vorinostat is an FDA-approved histone deacetylase inhibitor (HDACi) that has proven clinical success in some patients; however, it remains unclear why certain patients remain unresponsive to this agent and other HDACis. Constitutive STAT (signal transducer and activator of transcription) activation, overexpression of prosurvival Bcl-2 proteins and loss of HR23B have been identified as potential biomarkers of HDACi resistance; however, none have yet been used to aid the clinical utility of HDACi. ...[more]