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MetabolomicsDivergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition
Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucity of knowledge regarding the biology of T. congole...
2021-07-20 | MTBLS2372 | MetaboLights
MetabolomicsL-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS positive mode)

The overuse of antibiotics has made public health and safety face a serious crisis. It is urgent to develop new clinical treatment methods to combat drug-resistant bacteria to alleviate the health crisis. The efficiency of antibiotics is closely related to the metabolic state of bacteria. However...

2023-05-02 | MTBLS7711 | MetaboLights
MetabolomicsL-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS negative mode)

The overuse of antibiotics has made public health and safety face a serious crisis. It is urgent to develop new clinical treatment methods to combat drug-resistant bacteria to alleviate the health crisis. The efficiency of antibiotics is closely related to the metabolic state of bacteria. However...

2023-05-02 | MTBLS7713 | MetaboLights
MetabolomicsThe efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting “undruggable” proteins and several PROTACs have reached the stage of clinical candidate...
2025-07-17 | MTBLS11394 | MetaboLights
MetabolomicsMetabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei
In vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to be more biologically relevant, or to optimise growth, is traditionally a laborious task. Emerging metabolomics technology enables rapid evaluation of ...
2015-05-14 | MTBLS49 | MetaboLights
TranscriptomicsDRUG-seq data of HepG2 treated with compounds
HepG2 treated with 40 compounds (3 concentrations, 0.1xCmax, Cmax and 10xCmax) and vehicle for 7 h. Compounds have different degree of drug-induced liver injury concern. Data for Figure 2 in connected publication.
ORGANISM(S): Homo sapiens 
2026-01-16 | E-MTAB-15601 | biostudies-arrayexpress
TranscriptomicsDRUG-seq data of primary human hepatocyte spheroids treated with compounds
Primary human hepatocytes treated with 40 compounds (3 concentrations, 0.1xCmax, Cmax and 10xCmax) and vehicle for 7 h. Compounds have different degree of drug-induced liver injury concern. Data for Figure 2 in connected publication.
ORGANISM(S): Homo sapiens 
2026-01-16 | E-MTAB-15612 | biostudies-arrayexpress
MetabolomicsRegulation of drug resistance to enrofloxacin in Pasteurella multocida strains from cattle by quorum-sensing acyl-homoserine lactone signaling molecules

Pasteurella multocida (Pm) is a significant cause of respiratory disease in beef cattle, with serious consequences for the cattle industry. The bacterial quorum-sensing (QS) system is used for communication and regulation of various processes, including bacterial growth, virulence, biofilm format...

2025-12-18 | MTBLS13502 | MetaboLights
TranscriptomicsPrediction of drug sensitivity
Tumor cell lines and drug-resistant counterparts. These data support the publication Gyorffy et al, Oncogene 2005 (July), Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival. We contrasted the express...
ORGANISM(S): Homo sapiens 
2005-07-30 | E-GEOD-3034 | biostudies-arrayexpress
TranscriptomicsInduction of 1C Aldoketoreductases and Other Drug Dose-dependent Genes Upon Acquisition of Anthracycline Resistance
Recent studies have suggested that elevated expression of aldoketoreductase (AKR) 1C1 or 1C2 in tumour cells is associated with increased resistance to DNA damaging agents such as cisplatin and doxorubicin. However, it has not been shown whether selection of tumour cells for resistance to DNA-damag...
ORGANISM(S): Homo sapiens 
2008-07-16 | E-GEOD-12115 | biostudies-arrayexpress
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