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MetabolomicsThe apicomplexan parasite Toxoplasma gondii forms bradyzoite-containing tissue cysts that cause chronic and drug-tolerant infections.
Not available
ORGANISM(S): Toxoplasma gondii 
ST002051 | MetabolomicsWorkbench
TranscriptomicsGene expression profile of murine tolerant, self-antigen specific CD8 T cells
Genomewide microarray analysis of murine tolerant, self-antigen specific CD8 T cells to identify genes and pathways underlying peripheral T cell tolerance Gene signature of tolerant CD8 T cells was compared to the signatures of naïve T cells, memory T cells, rescued T cells (=tolerant T cells underg...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-32025 | biostudies-arrayexpress
TranscriptomicsDrug tolerance development of mouse Bcr/Abl pre-B ALL cells on irradiated MEFs
Although cure rates for acute lymphoblastic leukemia (ALL) have increased, development of resistance to drugs and patient relapse are common. The environment in which the leukemia cells are present during the drug treatment is known to provide significant survival benefit. Here, we have modeled this...
ORGANISM(S): Mus musculus 
2012-09-30 | E-GEOD-37286 | biostudies-arrayexpress
Transcriptomics3'mRNA-Seq of drug-tolerant medulloblastoma cell lines.
Stable cisplatin- and vincristine-tolerant Group 3 and SHH cell lines were generated by continuous drug exposure with dose escalation to identify mechanisms driving resistance to standard-of-care medulloblastoma therapy. Next-generation sequencing revealed a vastly different transcriptomic landscape...
ORGANISM(S): Homo sapiens 
2024-01-01 | E-MTAB-12686 | biostudies-arrayexpress
TranscriptomicsCheckpoint blockade immunotherapy relies on T-bet but not Eomes to induce effector function in tumor infiltrating CD8+ T cells
Coinhibitory receptor blockade is a promising strategy to boost immunity against a variety of human cancers. However, many patients still do not benefit from this treatment, and responders often experience immune-related toxicities. These issues highlight the need for improved understanding of check...
ORGANISM(S): Mus musculus 
2014-12-18 | E-GEOD-58722 | biostudies-arrayexpress
TranscriptomicsThree-dimensional low shear culture of Mycobacterium bovis BCG induces biofilm formation and antimicrobial drug tolerance
Mycobacteria naturally grow as corded biofilms in liquid media without detergent. Such detergent-free biofilm phenotypes may reflect the growth pattern of bacilli in tuberculous lung lesions. New strategies are required to treat tuberculosis that is responsible for more deaths each year than any oth...
ORGANISM(S): Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2 
2021-01-29 | E-MTAB-9904 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human liver transplant patients reveals a signature that could discriminate tolerant recipients from immunosuppression-dependent patients
mmunosuppressive drugs can be completely withdrawn in up to 20% of liver transplant recipients, commonly referred to as ‘operationally’ tolerant. Immune characterization of these patients, however, has not been performed in detail, and we lack tests capable of identifying tolerant patients among...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-11881 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of DNA methylation in drug-tolerant cancer cell subpopulations
Cancer relapse after curative treatment is thought to originate from drug-tolerant and invisible cancer cell subpopulations. Using cancer cell colonies emerging in the presence of drugs (drug-tolerant colonies, DTCs), we found that the drug-tolerant properties of DTCs are lost through a reversible m...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-69203 | biostudies-arrayexpress
GenomicsThe Ontogeny and Vulnerabilities of Lapatinib Drug Tolerant Persisters [Parental (P) vs. Drug-Tolerant Persister (DTP)]
The Ontogeny and Vulnerabilities of Lapatinib Drug Tolerant Persisters [Parental (P) vs. Drug-Tolerant Persister (DTP)]
PRJNA649434 | ENA
TranscriptomicsHeterogeneity in allospecific T cell function in transplant tolerant hosts determines susceptibility to rejection following infection
CD4+CD45.1+ TCR75/Rag-/- T cells (TCR75) were adoptively transferred into CD45.2+ B6 hosts either untransplanted and immunized with B/c donor splenocytes i.p. (UnTx+DST) to induce memory, or prior to transplantation of a B/c heart (HTx) in the presence of anti-CD154 (day 0, day 7, day 14) and DST (d...
ORGANISM(S): Mus musculus 
2023-09-29 | E-MTAB-13333 | biostudies-arrayexpress
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