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MetabolomicsRegulation of drug resistance to enrofloxacin in Pasteurella multocida strains from cattle by quorum-sensing acyl-homoserine lactone signaling molecules

Pasteurella multocida (Pm) is a significant cause of respiratory disease in beef cattle, with serious consequences for the cattle industry. The bacterial quorum-sensing (QS) system is used for communication and regulation of various processes, including bacterial growth, virulence, biofilm format...

2025-12-18 | MTBLS13502 | MetaboLights
MetabolomicsAtypical Molecular Basis for Drug Resistance to Mitochondrial AQ: A Function Inhibitors in Plasmodium falciparum
Not available
ORGANISM(S): Plasmodium falciparum 
ST001652 | MetabolomicsWorkbench
TranscriptomicsGenetic and molecular basis of drug resistance and species-specific drug action in Schistosome parasites
Oxamniquine resistance evolved in the human blood fluke (Schistosoma mansoni) in Brazil in the 1970s. We crossed parental parasites differing ~500-fold in drug response, determined drug sensitivity and marker segregation in clonally-derived F2s, and identified a single QTL (LOD=31) on chromosome 6. ...
ORGANISM(S): Schistosoma mansoni 
2013-12-05 | E-GEOD-51847 | biostudies-arrayexpress
TranscriptomicsYeast drug resistance gene mutants in glucose or ammonium limited chemostats
Homozygous deletion mutants of drug resistance genes QDR3 and PDR3 and the homozygous deletion of HO (control) were grown in ammonium limited or glucose limited synthetic defined medium in aerated, pH controlled chemostats at a dilution rate of 0.1hr-1. Samples were collected at steady state.
ORGANISM(S): Saccharomyces cerevisiae 
2013-10-23 | E-MTAB-707 | biostudies-arrayexpress
TranscriptomicsInduction of 1C Aldoketoreductases and Other Drug Dose-dependent Genes Upon Acquisition of Anthracycline Resistance
Recent studies have suggested that elevated expression of aldoketoreductase (AKR) 1C1 or 1C2 in tumour cells is associated with increased resistance to DNA damaging agents such as cisplatin and doxorubicin. However, it has not been shown whether selection of tumour cells for resistance to DNA-damag...
ORGANISM(S): Homo sapiens 
2008-07-16 | E-GEOD-12115 | biostudies-arrayexpress
ProteomicsOverexpression of SLC2A1, ALDOC and PFKFB4 in the glycolysis pathway drives strong drug resistance in 3D HeLa tumor cell spheroids
The three-dimensional (3D) tumor spheroid model exhibits enhanced fidelity in replicating the tumor microenvironment and demonstrates exceptional resistance to clinical drugs compared to the two-dimensional (2D) monolayer model. In this study, we used multi-omics (transcriptome, proteomics, and me...
ORGANISM(S): Homo Sapiens 
2024-06-12 | PXD053058 |
TranscriptomicsDrug tolerance development of mouse Bcr/Abl pre-B ALL cells on irradiated MEFs
Although cure rates for acute lymphoblastic leukemia (ALL) have increased, development of resistance to drugs and patient relapse are common. The environment in which the leukemia cells are present during the drug treatment is known to provide significant survival benefit. Here, we have modeled this...
ORGANISM(S): Mus musculus 
2012-09-30 | E-GEOD-37286 | biostudies-arrayexpress
TranscriptomicsMicroRNAs characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia
MicroRNAs (miRNAs) regulate activity of protein-coding genes including those involved in hematopoietic cancers. The goal of the current study was to explore which miRNAs are unique for seven different subtypes of pediatric acute lymphoblastic leukemia (ALL). Therefore, the expression levels of 397 m...
ORGANISM(S): Homo sapiens 
2011-02-11 | E-GEOD-23024 | biostudies-arrayexpress
TranscriptomicsRedefining the Relevance of Established Cancer Cell Lines to the Study of Clinical Anti-Cancer Drug Resistance
Although in vitro models have been a cornerstone of anti-cancer drug development, their direct applicability to clinical cancer research has actually been uncertain. Using a state-of-the-art Taqman-based qRT-PCR assay, we investigated the multidrug resistance (MDR) transcriptome of six cancer types,...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-30034 | biostudies-arrayexpress
GenomicsIdentification of drug resistance genes in melanoma
Our aim is to analyze the genome of human melanoma cell lines and short term culture from human melanoma samples in order to identify genes that confer drug resistance to clinically relevant targeted therapies. We will perform whole-exome sequencing, copy number variation analysis and methylome anal...
EGAS00001000617 | EGA
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