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MetabolomicsThe apicomplexan parasite Toxoplasma gondii forms bradyzoite-containing tissue cysts that cause chronic and drug-tolerant infections.
Not available
ORGANISM(S): Toxoplasma gondii 
ST002051 | MetabolomicsWorkbench
Transcriptomics3'mRNA-Seq of drug-tolerant medulloblastoma cell lines.
Stable cisplatin- and vincristine-tolerant Group 3 and SHH cell lines were generated by continuous drug exposure with dose escalation to identify mechanisms driving resistance to standard-of-care medulloblastoma therapy. Next-generation sequencing revealed a vastly different transcriptomic landscape...
ORGANISM(S): Homo sapiens 
2024-01-01 | E-MTAB-12686 | biostudies-arrayexpress
TranscriptomicsDrug tolerance development of mouse Bcr/Abl pre-B ALL cells on irradiated MEFs
Although cure rates for acute lymphoblastic leukemia (ALL) have increased, development of resistance to drugs and patient relapse are common. The environment in which the leukemia cells are present during the drug treatment is known to provide significant survival benefit. Here, we have modeled this...
ORGANISM(S): Mus musculus 
2012-09-30 | E-GEOD-37286 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of DNA methylation in drug-tolerant cancer cell subpopulations
Cancer relapse after curative treatment is thought to originate from drug-tolerant and invisible cancer cell subpopulations. Using cancer cell colonies emerging in the presence of drugs (drug-tolerant colonies, DTCs), we found that the drug-tolerant properties of DTCs are lost through a reversible m...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-69203 | biostudies-arrayexpress
GenomicsThe Ontogeny and Vulnerabilities of Lapatinib Drug Tolerant Persisters [Parental (P) vs. Drug-Tolerant Persister (DTP)]
The Ontogeny and Vulnerabilities of Lapatinib Drug Tolerant Persisters [Parental (P) vs. Drug-Tolerant Persister (DTP)]
PRJNA649434 | ENA
GenomicsHistone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma [RKI1_DTPs_RNAseq]
Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma [RKI1_DTPs_RNAseq]
PRJNA1122510 | ENA
Genomics3D chromatin architecture of drug-tolerant cancer cells at single-cell resolution [scHi-C]
3D chromatin architecture of drug-tolerant cancer cells at single-cell resolution [scHi-C]
PRJNA800252 | ENA
GenomicsDrug tolerant persister cells of EGFR-mutant cell line under kinase-inhibitor combination
Drug tolerant persister cells of EGFR-mutant cell line under kinase-inhibitor combination
PRJEB62843 | ENA
TranscriptomicsDrug tolerant persister cells of EGFR-mutant cell line under kinase-inhibitor combination
Drug tolerant persister cells of EGFR-mutant PC9 cell lines surviving treatment with kinase inhibitor combination. Cells were treated with combination of erlotinib, osimertinib, trametinib and dasatinib and surviving cells were harvested for RNA extraction. 3' UTR RNA-seq profiles were compared to p...
ORGANISM(S): Homo sapiens 
2023-06-30 | E-MTAB-13045 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of drug-tolerant cancer cell subpopulation
Cancer relapse occurs even after curative treatment, suggesting the existence of undetectable cancer cell subpopulations and their drug-tolerant potential. We found that the number of drug-tolerant colonies (DTCs) was significantly suppressed by an RNA polymerase II (RNAPII) inhibitor, alpha-amaniti...
ORGANISM(S): Homo sapiens 
2015-01-30 | E-GEOD-65419 | biostudies-arrayexpress
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