Dry eye disease

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CHEBI ID

CHEBI:18132 (5)
CHEBI:18237 (5)
CHEBI:16811 (5)
CHEBI:28300 (5)
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Metabolite Name

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Lab affiliation

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (5)
Centre for Ocular Regeneration (CORE), Prof. Brien Holden Eye Research Centre (BHERC), L V Prasad Eye Institute, Hyderabad, Telangana, India (2)
University of Houston, Houston, TX 77204 (2)
Bascom Palmer Eye Institute University of Miami (1)
Center for Biotechnology & Genomic Medicine, Dept. of Population Health Sciences Medical College of Georgia at Augusta University (1)
Core Facility Proteomics, Department of Clinical Chemistry, University Medical Center Goettingen, Germany (1)
Department of Biological Sciences University of Delaware Newark, DE, USA. (1)
Department of Neurology, Yale School of Medicine, Yale University, new haven CT, USA (1)
Department ogf Pharmacy, University "G. d'Annunzio", Chieti, Italy (1)
Functional Proteomics Medizinisches Proteom-Center Germany (1)
Hardt Scientifc Consulting (1)
Institut National de la Santé et de la Recherche Médicale INSERM UMRS 968, CNRS UMR 7210, Institut de la Vision, IHU ForeSight, Sorbonne Université UM80, 75012 Paris, France (1)
LBPC-PPC, Montpellier University, IRMB CHU Montpellier, INM INSERM, Montpellier, Occitanie, France (1)
Professor, Department of Cell and Regenerative Biology Professor, Department of Chemistry Director of Mass Spectrometry Human Proteomics Program School of Medicine and Public Health University of Wisconsin-Madison (1)
Senior Principal Research Scientist, Head, Ocular Proteomics Platform Singapore Eye Research Institute Singapore (1)
Wenzhou Medical University (1)
Yale University (1)

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Tear lipidomics profiling reveals inflammatory dry eye disease-associated lipid metabolic remodeling at the ocular surface

This study aimed to investigate whether inflammatory dry eye disease (DED) is accompanied by abnormal lipid metabolic remodeling at the ocular surface. Tear samples were collected from patients with DED and matched healthy controls. Lipidomics profiling was performed using LC–MS/MS with a standardiz...

2026-04-03 | MTBLS14218 | MetaboLights

Tear lipidomics profiling reveals ocular-surface lipid remodeling associated with organelle stress in a mouse model of inflammatory dry eye disease

This study aimed to determine whether dry eye disease (DED) is accompanied by ocular-surface lipid remodeling and whether such changes converge on organelle stress–associated pathways in a mouse model of inflammatory dry eye. Tear samples were collected from mice and analyzed by LC–MS/MS–based non-t...

2026-04-04 | MTBLS14217 | MetaboLights

Effect of acupuncture on tear proteomics in patients with video display terminal-related dry eye

In our study, the tear proteome was compared with identify possible mechanisms and biomarkers for predicting acupuncture effectiveness in VDT-related dry eye. The results showed that the Ocular Surface Disease Index (OSDI) scores were significantly different between the acupuncture group (AC group) ...

ORGANISM(S): Homo Sapiens

2024-04-24 | PXD051759 |

Alterations of fecal microbiota and plasma metabolome in patients with Parkinson's disease with rapid eye movement sleep disorder

Objectives: Patients with Parkinson's disease (PD) with probable Rapid eye movement sleep Behavior Disorder (RBD) (PD-RBD), a specific subtype of PD, is characterized by the presence of more severe motor and non-motor symptoms. This study aimed to elucidate the characteristics and interactions of...

2025-05-07 | MTBLS11094 | MetaboLights

Global Metabonomic and Proteomic Analysis of Human Conjunctival Epithelial Cells (IOBA-NHC) in Response to Hyperosmotic Stress

“Dry eye” is a multi-factorial inflammatory disease affecting the ocular surface. Tear hyperosmolarity in dry eye contributes to inflammation and cell damage. Recent research efforts on dry eye have been directed towards biomarker discovery for diagnosis, response to treatment and disease mechanisms...

2015-08-31 | MTBLS214 | MetaboLights

Association of IL-8 and IL-18 Expression with Histone-Associated NETosis in Aqueous-Deficient and Evaporative Dry Eye Disease

Purpose: Dry eye disease (DED) is a chronic inflammatory disorder of the ocular surface; however, the upstream immune mechanisms contributing to DED are complex and unclear. This study aimed to identify differentially expressed tear fluid proteins in patients with DED and elucidate the underlying di...

ORGANISM(S): Homo sapiens (Human)

2026-09-07 | PXD075862 | Pride

Association of IL-8 and IL-18 Expression with Histone-Associated NETosis in Aqueous-Deficient and Evaporative Dry Eye Disease

ORGANISM(S): Homo sapiens (Human)

2026-09-07 | PXD075754 | Pride

Tear proteomics Neutrophil degranulation Histones Ocular surface Dry eye And inflammation

Human Tear using MALDI-TOF-MS for Dry Eye syndrome

Tears are a biological fluid that has diagnostic potential for ocular diseases. Extracellular vesicles (EVs), wildly detected in various biofluids including tears, are nanoparticles released by living cells and considered as promising detection sources for non-invasive liquid biopsy. Understanding t...

ORGANISM(S): Homo sapiens (Human)

2020-08-20 | PXD020217 | Pride

Human Maldi-tof ms Tear Dry eye syndrome Extracellular vesicles

miR204-containing exosome ameliorates GVHD-associated dry eye disease

PRJNA701305 | ENA

scRNAseq of corneal epithelium in dry eye disease

PRJNA756968 | ENA

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