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ProteomicsDepletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation
DNA double strand break (DSB) repair through homologous recombination (HR) is crucial to maintain genome stability. DSB resection generates a single strand DNA intermediate, which is crucial for the HR process. We used a synthetic DNA structure, mimicking a resection intermediate, as a bait to ident...
ORGANISM(S): Homo sapiens (Human) 
2019-02-26 | PXD012045 | Pride
Rna binding proteins  hnrnpd  dna damage  dna end resection  rna binding proteins  r-loop 
UnknownPHF11 promotes DSB resection, ATR signaling, and HR.
Not available
S-EPMC5287112 | biostudies-literature
GenomicsDbf4-dependent kinase promotes cell-cycle controlled resection of DNA double strand breaks and repair by homologous recombination
DNA double-strand breaks (DSBs) can be repaired by several pathways. In eukaryotes, repair pathway choice – the cellular decision making underlying DSB repair – occurs at the level of DSB resection and is controlled by the cell cycle. Upon cell cycle-dependent activation, cyclin-dependent kinases (C...
ORGANISM(S): Saccharomyces cerevisiae 
2024-02-22 | GSE233549 | GEO
TranscriptomicsThree-dimensional proximity mapping of the DRGFP DNA double-strand break site in U2OS cells
We mapped the DNA sequences located in physical proximity to an I-SceI endonuclease-dependent DNA double-strand break (DSB) site to be able to study the impact of DSBs on the break-associated chromatin micro-environment. The I-SceI DSB site is part of a DRGFP transgene that serves as a reporter for ...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-58563 | biostudies-arrayexpress
ProteomicsProtection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region
RIF1 is a multifunctional protein that plays key roles in the regulation of DNA processing. During repair of DNA double-strand breaks (DSBs), RIF1 functions in the 53BP1-Shieldin pathway that inhibits resection of DNA ends to modulate the cellular decision on which repair pathway to engage. Under co...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-14 | PXD031972 | Pride
Sq motifs Rif1 Dsb resection inhibition Dna replication fork protection Intrinsically disordered region 
UnknownUbcH7 regulates 53BP1 stability and DSB repair.
Not available
S-EPMC4267386 | biostudies-literature
GenomicsDbf4-dependent kinase promotes cell-cycle controlled resection of DNA double strand breaks and repair by homologous recombination
Dbf4-dependent kinase promotes cell-cycle controlled resection of DNA double strand breaks and repair by homologous recombination
PRJNA976649 | ENA
UnknownREV7 counteracts DNA double-strand break resection and affects PARP inhibition.
Not available
S-EPMC4671316 | biostudies-literature
Unknown53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.
Not available
S-EPMC6072559 | biostudies-literature
UnknownResection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae.
Not available
S-EPMC4541074 | biostudies-literature
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