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TranscriptomicsCleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF-{kappa}B Activation
Proper regulation of nuclear factor κB (NF-κB) transcriptional activity is required for normal lymphocyte function, and deregulated NF-κB signaling can facilitate lymphomagenesis. We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated ly...
ORGANISM(S): Homo sapiens 
2011-01-30 | E-GEOD-25527 | biostudies-arrayexpress
Genomicsena-DATASET-BCI-18-03-2015-12:48:54:303-380 - samples
Whole exome sequencing data of 5 patients diagnosed with FL that had undergone several relapse episodes without evidence of transformation
EGAD00001001301 | EGA
GenomicsRecurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Follicular lymphoma (FL) is an incurable B-cell malignancy characterized by the t(14;18) and mutations in one or more components of the epigenome. Whilst frequent gene mutations in signaling pathways, including JAK-STAT, NOTCH and NF-κB, have also been defined, the spectrum of these mutations typic...
EGAS00001001190 | EGA
GenomicsBarts Cancer Institute - Follicular Lymphoma Whole Genome Sequencing Project Data Access Committee
Data Access Committee EGAC00001000086
EGAC00001000086 | EGA
Genomicsena-DATASET-SC-16-09-2014-14:22:12:125-153 - samples
Description not provided
EGAD00001001014 | EGA
Genomicsena-DATASET-SC-16-09-2014-14:25:48:324-154 - samples
Description not provided
EGAD00001001015 | EGA
GenomicsOrigins and functional consequence of somatic mitochondrial DNA mutations
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mitochondrial DNA (mtDNA) are unclear. Here, we analysed soma...
EGAS00001000968 | EGA
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