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GenomicsHomo sapiens strain:DU145
Homo sapiens Transcriptome DU145
PRJNA970841 | ENA
TranscriptomicsControls and CNTN1 overexpression in DU145 cells and CNTN1 knockdown in DU145 cell-derived prostate cancer stem-like cells
Prostate cancer stem-like cells were derived from DU145 cells as suspension spheres. DU145 cells were transduced with a CNTN1 over expressing retroviral vector and a control empty vector. DU145 spheres were transduced using a retroviral-based shRNA vector against CNTN1 and a scrambled control shRN...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-MTAB-4118 | biostudies-arrayexpress
ProteomicsStable Cas9 Expression on Cell Growth Regulation Through mTORC2 Activation Facilitation
CRISPR, widely used for gene editing, relies on bacterial endonucleases like Cas9 to study gene functions and develop therapies. However, its potential effects on mammalian cellular responses and behavior remain unclear. Here, we systematically profiled effects of stable Cas9 expression on growth of...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD064062 | Pride
Du145 Mda-mb-231 
TranscriptomicsExpress data from Du145 cells
The retinoblastoma (Rb) tumor suppressor is often inactivated in cancers. To identify genes that can be used to specifically target such cancers, we carried out a genetic screen in Drosophila. We identified gig (fly TSC2) and found that inactivation of rbf (fly Rb) and gig synergistically induced ce...
ORGANISM(S): Homo sapiens 
2010-04-14 | E-GEOD-21147 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of Du145, PC3 and LNCaP human prostate cancer cell lines
Study aimed at evaluating differences in Du145, PC3 and LNCaP human prostate cancer cells treated with ATX-101 and docetaxel for 24h.
ORGANISM(S): Homo sapiens 
2017-12-31 | E-MTAB-4858 | biostudies-arrayexpress
TranscriptomicsExpression data of HGF/cMET pathway in prostate cancer DU145 cell line
DU145 prostate cancer cells were treated with 25 ng/ml hepatocyte growth factor (HGF) or vehicle for 2, 8, or 24 hours. HGF stimulates the cMET protein, a tyrosine kinase transmembrane protein. The aim of this study is to determine the role of the HGF/cMET pathway in immature cells of established pr...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-16659 | biostudies-arrayexpress
GenomicsEpigenome analysis of DU145 samples [II]
Epigenome analysis of DU145 samples [II]
PRJNA768880 | ENA
TranscriptomicsEffect of FGF19 and TNFalpha on human DU145 prostate cancer cells
DU145 prostate cancer cells were treated with 50 ng/ml FGF19 and 50 ug/ml heparin, or 10 ng/ml TNFalpha, or both drug treatment groups
ORGANISM(S): Homo sapiens 
2010-07-09 | E-GEOD-22807 | biostudies-arrayexpress
TranscriptomicsExpression data from DU145 cells treated with STAT3 siRNA
Activation of Signal Transducer and Activator of Transcription 3 (STAT3) is common in prostate cancers. STAT3 may induce cell proliferation and resistance to apoptosis, as well as promote tumor angiogenesis, invasion, and migration by activating gene expression. Many STAT3-dependent transcriptional ...
ORGANISM(S): Homo sapiens 
2010-12-07 | E-GEOD-25867 | biostudies-arrayexpress
GenomicsEpigenome analysis of DU145 samples
Epigenome analysis of DU145 samples
PRJNA732681 | ENA
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