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ProteomicsAdipocyte vesicles: ‘all-in-one’ packages that stimulate tumor mitochondrial metabolism and dynamics
Extracellular vesicles are emerging key actors in adipocyte communication. Notably, small extracellular vesicles shed by adipocytes promote melanoma aggressiveness through fatty acid oxidation, with a heightened effect in obesity. However, the vesicular actors and cellular processes involved remain ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-01-09 | PXD014487 | Pride
Exosome / fatty acid oxidation / lipophagy / melanoma / obesity / lc-msms 
ProteomicsHadBD dehydratase from Mycobacterium tuberculosis FAS-II: a singular structure for a unique function
Mycolic acids (MAs) are a unique class of lipids that are essential for viability, virulence and persistence of Mycobacterium tuberculosis (Mtb). Therefore, enzymes involved in MAs biosynthesis represent important class of drug targets. We previously showed that (3R)-hydroxyacyl-ACP dehydratase (HAD...
ORGANISM(S): Mycobacterium bovis BCG str. Pasteur 1173P2 
2024-03-21 | PXD043977 | Pride
(3r)-hydroxyacyl-acp dehydratase Structure-function relationships. Mycolic acids Hydratase 2 Mycobacterium tuberculosis Hotdog fold Crystal structure Catalytic subunit Substrate specificity Fatty acid synthase type ii system 
ProteomicsHuman bone marrow comprise atypical adipocytes with specific lipid metabolism
Under caloric restriction, bone marrow adipocytes (BM-Ad) do not decrease in size conversely to white adipocytes, suggesting their unique metabolic properties. We compared human primary BM-Ad with paired subcutaneous adipocytes (SC-Ad) using proteomic and lipidomic approaches. We found that while SC...
ORGANISM(S): Homo sapiens (Human) 
2020-01-29 | PXD016322 | Pride
Lc-msms Label free quantificatio Human Bone marrow adipocytes 
ProteomicsLack of fibro-inflammatory response in human mammary adipose tissue in obesity
Background Understanding how obesity impacts human mammary adipose tissue (MAT) biology is crucial for deciphering its role in mammary epithelium during both physiological and pathophysiological processes, including breast cancer. Hypertrophic mammary adipocytes and Crown-like Structures are present...
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD050896 | Pride
Mammary adipose tissue-obesity-fibrosis-inflammation 
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