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ProteomicsMolecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor
The Duffy antigen receptor, also known as FY glycoprotein or CD234, is a seven transmembrane (7TM) protein expressed primarily at the surface of red blood cells, and it displays strikingly promiscuous binding to multiple pro- and anti-inflammatory chemokines. Here, we comprehensively profile transdu...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD044876 | Pride
Duffy antigen receptor G protein-coupled receptors Chemokine receptors Cellular signaling Cryogenic-electron microscopy Phosphoproteomics 
ProteomicsGlobal interactomics analysis of the human Duffy antigen receptor for chemokines
The Duffy antigen receptor for chemokines or DARC is a seven trans-membrane glycoprotein that is expressed primarily on the surface of red blood cells. Additionally, it is also expressed on the surface of post-venular endothelial cells, Purkinje cells of the cerebellum, inner ear hair cells, cells o...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051602 | Pride
Duffy antigen receptor G protein-coupled receptors Chemokine receptors Cellular signaling Cryogenic-electron microscopy 
ProteomicsInvasion preferences suggest a possible role for Plasmodium falciparum parasites in the expansion of Duffy negativity in West and Central Africa
Duffy antigen receptor for chemokines (DARC) is the primary red blood cell (RBC) receptor for invasion of human RBCs by Plasmodium vivax and Plasmodium knowlesi merozoites. By contrast, Plasmodium falciparum parasites, which are the dominant cause of malaria in West and Central Africa, use multiple ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD065766 | Pride
Plasma membrane profiling Rbc surface proteome Duffy-negative rbc surface proteome Tmt 
UnknownThe Duffy antigen receptor for chemokines regulates asthma pathophysiology.
Not available
S-EPMC5578916 | biostudies-literature
UnknownGene encoding Duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations.
Not available
S-EPMC2582596 | biostudies-literature
UnknownPlasmodium vivax GPI-anchored micronemal antigen (PvGAMA) binds human erythrocytes independent of Duffy antigen status.
Not available
S-EPMC5069673 | biostudies-literature
UnknownMolecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor.
Not available
S-EPMC11349380 | biostudies-literature
GenomicsPlasmodium knowlesi can adapt to infect Duffy-negative Erythrocytes
Plasmodium knowlesi can adapt to infect Duffy-negative Erythrocytes
PRJEB88498 | ENA
UnknownErythrocyte Duffy antigen receptor for chemokines (DARC): diagnostic and therapeutic implications in atherosclerotic cardiovascular disease.
Not available
S-EPMC4001982 | biostudies-literature
UnknownDuffy antigen receptor for chemokines gene polymorphisms and malaria in Mangaluru, India.
Not available
S-EPMC6760058 | biostudies-literature
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