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ProteomicsA H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium
BackgroundThe ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repressive complex 1 (PRC1), whose recruitment is H3K27me3-dependent. Yet it is unclear how H3K27me3 contri...
ORGANISM(S): Paramecium tetraurelia 
2026-03-03 | PXD065449 | Pride
ProteomicsA histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium
To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms. Small RNAs, 20-30 nucleotides in length, bind to PIWI proteins and guide them to nascent transcripts by sequence complementarity, triggering the recruitm...
ORGANISM(S): Paramecium tetraurelia 
2025-09-22 | PXD063336 | Pride
Histone methyltransferase Programmed dna elimination Prc2 Small rna Paramecium 
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