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TranscriptomicsGlobal changes in gene expression in dermal fibroblasts with in vivo and in vitro deletion of the RBP-Jk gene
It is currently unclear whether tissue changes surrounding multifocal epithelial tumors are a cause or consequence of cancer. Here, we provide evidence that loss of mesenchymal Notch/CSL signaling causes tissue alterations, including stromal atrophy and inflammation, which precede and are potent tri...
ORGANISM(S): Mus musculus 
2012-06-11 | E-GEOD-36359 | biostudies-arrayexpress
UnknownLonger Follow-Up Confirms Relapse-Free Survival Benefit With Adjuvant Dabrafenib Plus Trametinib in Patients With Resected BRAF V600-Mutant Stage III Melanoma.
Not available
S-EPMC6286159 | biostudies-literature
TranscriptomicsTranscription profiling of human melanomas to identify metastatic potential defined by specific gene expression profiles with no BRAF signature
The molecular biology of metastatic potential in melanoma has been studied many times previously and changes in the expression of many genes have been linked to metastatic behaviour. What is lacking is a systematic characterization of the regulatory relationships between genes whose expression is re...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4841 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human melanomas to assess metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature (Mannheim).
The molecular biology of metastatic potential in melanoma has been studied many times previously and changes in the expression of many genes have been linked to metastatic behaviour. What is lacking is a systematic characterization of the regulatory relationships between genes whose expression is re...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4843 | biostudies-arrayexpress
GenomicsRomidepsin and azacitidine synergize in their epigenetic modulatory effects to induce apoptosis in CTCL
We demonstrate that the combination of the HDAC inhibitor, romidepsin, and the demethylating agent, azacitidine, exerts synergistic anti-proliferative effects and induction of apoptosis involving activation of the caspase cascade in CTCL cell lines as well as CD4+ T cells derived from patients with ...
ORGANISM(S): Homo sapiens 
2016-03-30 | E-GEOD-66732 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human melanomas to determine metastatic potential defined by specific gene expression profiles with no BRAF signature.
The molecular biology of metastatic potential in melanoma has been studied many times previously and changes in the expression of many genes have been linked to metastatic behaviour. What is lacking is a systematic characterization of the regulatory relationships between genes whose expression is re...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4845 | biostudies-arrayexpress
ProteomicsProteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases
Background MAP kinase inhibitor (MAPKi) therapy for BRAF mutated melanoma is characterized by high response rates but also development of drug resistance within a median progression-free survival (PFS) of 9 to 12 months. Understanding mechanisms of resistance and identifying effective therapeutic al...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082948 | MassIVE
TranscriptomicsGenetic characterization of tumor-stage mycosis fungoides
Mycosis fungoides patients who develop tumors or extracutaneous involvement usually have a poor prognosis with no curative therapy available so far. In the present EORTC multicenter study, the genomic profile of 41 skin biopsies from tumor-stage mycosis fungoides was analyzed using a high-resolution...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-18098 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of human blood dendritic cells from buffy coats and in vitro differentiated dendritic cells from cord blood CD34 + stem cells
To compare human dendritic cells from peripheral blood, in vitro cultures with dendritic cells from human tumor tissues in publicly available single-cell RNA-seq datasets we performed single-cell RNA-seq of human blood dendritic cells and in vitro differentiated dendritic cells from cord blood CD34 ...
ORGANISM(S): Homo sapiens 
2022-06-15 | E-MTAB-11735 | biostudies-arrayexpress
ProteomicsSPANX immunoprecipitation analysis by mass spectrometry
A375 cells transduced with empty pLVX or pLVX-SPANXA-FLAG were subjected to immunoprecipitation using Flag beads. Elution from beads was performed by incubation with 3XFlag peptide for 1h at 4 C and eluates were subjected to tryptic digestion followed by LC-MS/MS, as described previously (PMID: 3099...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-11-24 | MSV000084617 | MassIVE
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