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TranscriptomicsChromatin immunoprecipitation of mouse and human cell lines and tissues using E2F4 antibodies
Despite being expressed in most tissues, a number of mammalian process-specific transcriptional regulators, such as those involved in cell cycle and immune responses, often have profound tissue-specific phenotypes. The mechanism underlying this effect is poorly understood. We chose to investigate ...
ORGANISM(S): Mus musculus 
2007-07-05 | E-TABM-272 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E2F4 double knockout mice and heterozygous littermates
We considered the possibility that removal of E2F4, as a key regulator of cellular quiescence, would cause systemic perturbations in the expression of E2F4 bound genes involved in cell cycle and proliferation. To test whether these pertubrations were reflected in the adult tissues' gene expression p...
ORGANISM(S): Mus musculus 
2007-06-14 | E-MEXP-1131 | biostudies-arrayexpress
TranscriptomicsMethylation profiling by array of human and TC1 and TC0 mouse strain livers and testes to study human repetitive elements on human chromosome 21 in a heterologous mouse environment
The aim of this project is to study human repetitive elements on human chromosome 21 in a heterologous mouse environment (Tc1 mouse). To determine the unbiased regulation of the human genome, suppressed regions of human chromosome 21 were identified in vivo in liver and testes of human and Tc1 mouse...
ORGANISM(S): Mus musculus 
2012-12-13 | E-MTAB-1304 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of key transcriptional regulators, RNA polymerase II and histone methylation in mouse and human liver to measure binding at regulatory regions of homologous genes
To identify experimentally both conserved and evolving aspects of transcriptional regulation, we have measured the binding of key transcriptional regulators, RNA polymerase II and histone methylation in mouse and human liver at regulatory regions of homologous genes. As expected, the set of genes f...
ORGANISM(S): Homo sapiens 
2008-05-08 | E-TABM-144 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human HNF3b and E2F4, and mouse NeuroD1, for THEME analysis
Genome-wide chromatin-immunoprecipitation (ChIP-chip) detects binding of transcriptional regulators to DNA in vivo at low resolution. Motif discovery algorithms can be used to discover sequence patterns in the bound regions that may be recognized by the immunoprecipitated protein. However, the disco...
ORGANISM(S): Mus musculus 
2006-05-09 | E-WMIT-8 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse blastocyst after embryo biopsy
Preimplantation Genetic Testing (PGT), which encompasses both Preimplantation Genetic Diagnosis (PGD) and Preimplantation Genetic Screening (PGS), is a form of prenatal screening done on embryos conceived through assisted reproduction techniques (ART) prior to the initiation of pregnancy to ensure t...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-11206 | biostudies-arrayexpress
UnknownIC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice.
Not available
S-EPMC11303442 | biostudies-literature
UnknownQuantitative susceptibility mapping identifies hippocampal and other subcortical grey matter tissue composition changes in temporal lobe epilepsy.
Not available
S-EPMC10502681 | biostudies-literature
TranscriptomicsBiased gene expression in early honeybee larval development (microarray)
Female larvae of the honeybee (Apis mellifera) develop into either queens or workers depending on nutrition during larval development. This nutritional stimulus triggers different developmental trajectories, resulting in adults that differ in physiology, behaviour and life-span. To understand how t...
ORGANISM(S): Apis mellifera 
2013-11-13 | E-GEOD-52288 | biostudies-arrayexpress
UnknownRadiograph accelerated detection and identification of cancer in the lung (RADICAL): a mixed methods study to assess the clinical effectiveness and acceptability of Qure.ai artificial intelligence software to prioritise chest X-ray (CXR) interpretation.
Not available
S-EPMC11418533 | biostudies-literature
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