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TranscriptomicsTargeting Csnk1a1 induces selective p53-dependant killing of leukemia stem cells
We found found that casein kinase 1 alpha (Csnk1a1), a serine threonine kinase and negative regulator of beta catenin, is essential for leukemia cells in vivo. We examined the effect of Csnk1a1 knowckdown by gene expression profiling in primary leukemia cells.
ORGANISM(S): Mus musculus 
2014-02-23 | E-GEOD-52928 | biostudies-arrayexpress
TranscriptomicsIn Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling
Primary leukemia stem cells (LSCs) reside in an in vivo microenvironment that supports the growth and survival of malignant cells. We used an in vivo short hairpin RNA (shRNA) screening approach to identify novel genes that are essential for primary murine MLL-AF9 acute myeloid leukemia (AML). We fo...
ORGANISM(S): Mus musculus 
2013-04-24 | E-GEOD-46307 | biostudies-arrayexpress
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