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ProteomicsMapping of mycobacterial lipolytic enzymes involved in triacylglycerol accumulation as intrabacterial lipid inclusions using multi-target inhibitor-like affinity-based probes
Mycobacteria are known for their unique and complex cell wall architecture, characterized by distinct lipid-rich outer layers, making lipid metabolism a central point of their physiological processes. One crucial aspect of all mycobacteria is their ability to metabolize host lipids and to accumulate...
ORGANISM(S): Mycobacterium abscessus 
2025-05-12 | PXD048770 | Pride
Mycobacterium Lc_msms Activity-based protein profiling  multitarget inhibitor-like affinity-based probes  lipid metabolism  cyclipostins & cyclophostin  oxadiazolone 
ProteomicsThe polyamino-isoprenyl enhancer NV716 potentializes the antibacterial activity of two families of multitarget inhibitors against the ESKAPEE bacterium Enterobacter cloacae – Part2 (Pseudomonas. aeruginosa)
The spread of antimicrobial resistance (AMR), coupled with the decline in antibiotic development, has become a major public health concern. Recent studies estimate that around 700,000 people die each year from infections caused by multidrug-resistant (MDR) bacteria. This led the WHO to publish the ...
ORGANISM(S): Pseudomonas aeruginosa BWHPSA046 
2025-02-27 | PXD052024 | Pride
Gram-negative bacteria  antibiotic resistance  drug enhancers  oxadiazolone derivatives  cyclipostins & cyclophostin analogs  activity based-protein profiling Lc-msms 
ProteomicsThe polyamino-isoprenyl enhancer NV716 potentializes the antibacterial activity of two families of multitarget inhibitors against the ESKAPEE bacterium Enterobacter cloacae, Part1bis (Enterobacter cloacae)
The spread of antimicrobial resistance (AMR), coupled with the decline in antibiotic development, has become a major public health concern. Recent studies estimate that around 700,000 people die each year from infections caused by multidrug-resistant (MDR) bacteria. This led the WHO to publish the E...
ORGANISM(S): Enterobacter cloacae 
2025-02-27 | PXD053955 | Pride
Gram-negative bacteria  antibiotic resistance  drug enhancers  oxadiazolone derivatives  cyclipostins & cyclophostin analogs  activity based-protein profiling 
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