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TranscriptomicsA novel class of alternative 3M-bM-^@M-^Y-terminal exons is involved in cell-cycle regulation by topoisomerase inhibitors
Alternative 3M-bM-^@M-^Y-terminal exons, which use intronic polyadenylation sites, are generally unconserved and lowly expressed, while the main gene products end in the last exon of genes. In this study, we discover a class of human genes, where the last exon appeared recently during evolution, and...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-53474 | biostudies-arrayexpress
Genomics
Comparative fly venom evolution
PRJNA361480 | ENA
TranscriptomicsRNA helicases DDX5 and DDX17 dynamically orchestrate transcription, microRNA and splicing programs in cell differentiation
RNA helicases DDX5 and DDX17 are members of a large family of highly conserved proteins involved in gene expression regulation, although their in vivo targets and activities in biological processes like cell differentiation, that requires reprogramming of gene expression programs at multiple levels,...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-57281 | biostudies-arrayexpress
ProteomicsER-RIME in wt-MCF7 and MCF7-LTED
Wild type (wt) MCF7 cells, modelling breast cancer at primary diagnosis, were cultured in phenol red-free RPMI supplemented with 10% FBS and 1nM estradiol (E2). Long-term oestrogen deprived (LTED) cell lines, which model resistance to endocrine therapy, were cultured in phenol red-free RPMI in the a...
ORGANISM(S): Homo sapiens (Human) 
2020-07-13 | PXD004648 | Pride
Breast cancer Mcf7 Rime Lc-ms/ms 
TranscriptomicsSplicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness
Both epigenetic and splicing regulation contribute to tumor progression, but the potential links between these two levels of gene-expression regulation in pathogenesis are not well understood. Here, we report that the mouse and human RNA helicases ddx17 and ddx5 contribute to tumor-cell invasiveness...
ORGANISM(S): Mus musculus 
2012-09-11 | E-GEOD-40737 | biostudies-arrayexpress
UnknownPLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance.
Not available
S-EPMC7426966 | biostudies-literature
TranscriptomicsCotranscriptional exon skipping in the genotoxic stress response
Pre-mRNA splicing is functionally coupled to transcription, and genotoxic stresses can enhance alternative exon inclusion by affecting elongating RNA polymerase II. We report here that various genotoxic stress inducers, including camptothecin, inhibit the interaction between EWS, an RNA polymerase I...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-21840 | biostudies-arrayexpress
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