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TranscriptomicsHeLa gene expression profile
Gene expression in HeLa cells was profiled using Affymetrix gene expression Human HG-U133_Plus_2 array. Transcript signal was mapped against the chromosome coordinates (probe-by-probe basis) using the HG-U133A_2 Annotations CSV file for hg18 build of the human genome provided by Affymetrix. Karnani...
ORGANISM(S): Homo sapiens 
2011-01-07 | E-GEOD-26471 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HeLa cells synchronized at the G1-S boundary and then sampled at 2-hour intervals during S-phase
The experimental strategy adopted to map this profile involved isolation of replication products from HeLa cells synchronized at the G1-S boundary by thymidine-aphidicolin double block. Cells released from the block were labeled with BrdU at every two-hour interval of the 10 hours of S-phase and DNA...
ORGANISM(S): Homo sapiens 
2006-11-02 | E-MEXP-708 | biostudies-arrayexpress
TranscriptomicsExtrachromosomal microDNAs and chromosomal microdeletions in normal tissues
We have identified tens of thousands of short extrachromosomal circular DNAs (microDNA) in mouse tissues as well as mouse and human cell lines. These microDNAs are 200-400 bp long, derived from unique non-repetitive sequence and are enriched in the 5' untranslated regions of genes, exons and CpG is...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-36088 | biostudies-arrayexpress
TranscriptomicsExpression data after miR-99a transfection in C4-2 prostate cancer cells
MicroRNAs (miRNAs) have been globally profiled in cancers but there tends to be poor agreement between studies including in the same cancers. Additionally, few putative miRNA targets have been validated. To overcome the lack of reproducibility, we profiled miRNAs by next generation sequencing and lo...
ORGANISM(S): Homo sapiens 
2010-12-29 | E-GEOD-26332 | biostudies-arrayexpress
GenomicsExtrachromosomal DNA (microDNA) in Human, Mouse and Chicken
MicroDNAs are <400-base long extrachromosomal circles found in mammalian cells. Tens of thousands of microDNAs were found in all tissue types, including sperm. MicroDNAs arose preferentially from areas with high gene density, high GC content, high exon density, promoters with activating chromatin ...
ORGANISM(S): Gallus gallus 
2015-05-08 | E-GEOD-68644 | biostudies-arrayexpress
TranscriptomicsMUNC downregulation decreases muscle differentiation
Gene expression profiling in differentiating C2C12 cells comparing control cells and MUNC-deprived cells RNA samples were isolated from 4 C2C12 samples: proliferating control (siC) cells, differentiating siC cells, proliferating and differentiating MUNC depleted (siMUNC) cells
ORGANISM(S): Mus musculus 
2014-11-27 | E-GEOD-63673 | biostudies-arrayexpress
TranscriptomicsMelanoma tissue samples from a clinical trial: no treatment vs. post-temsirolimus alone vs. post-combination temsirolimus and bevacizumab
To determine if treatment with a combined therapeutic regimen, which resulted in clinical benefit in a subset of patients in a clinical trial, alters miRNA expression in a way that may be used to guide treatment with these agents and to identify miRNAs that may be involved in the mechanism of action...
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-37131 | biostudies-arrayexpress
GenomicsHomo sapiens
Nuclear Scaffold Attachment Sites in HeLa Cells Across 1% of the Human Genome
PRJNA136529 | ENA
UnknownMelanoma tissue samples from a clinical trial: no treatment vs. post-temsirolimus alone vs. post-combination temsirolimus and bevacizumab
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-37131 | biostudies-other
TranscriptomicsStable Set8 effect on gene expression in U2OS cells
Ubiquitin-mediated proteolysis play a significant role in various biological processes including transcription, DNA repair and cell cycle progression. The identification of Set8 and Set8b (a splice isoform) histone H4K20 methyl transferase as a substrate for the cullin-based ubiquitin ligase (CRL4-C...
ORGANISM(S): Homo sapiens 
2010-09-18 | E-GEOD-24170 | biostudies-arrayexpress
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