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TranscriptomicsTranscriptomic profiling of peripheral blood mononuclear cells from healthy individuals
Substantial effort is currently devoted to identifying cancer-associated alterations using genomics. Here, we show that standard blood collection procedures rapidly change the transcriptional and post-transcriptional landscapes of hematopoietic cells, resulting in biased activation of specific biolo...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-58335 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of bone marrow cells from healthy individuals
We performed whole-genome transcriptomic profiling of RNA from mononuclear cells from bone marrow aspirates taken from healthy individuals. This study complements GSE58335: transcriptomic profiling of peripheral blood mononuclear cells from healthy individuals. High-throughput sequencing was done us...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-61410 | biostudies-arrayexpress
TranscriptomicsTherapeutic targeting of myeloid leukemias with spliceosomal mutations through modulation of splicing catalysis
Mutations in spliceosomal genes are commonly found in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). These mutations occur at highly restricted amino acid residues and perturb normal splice site and exon recognition. Spliceosomal mutations are always heterozygous and...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-74064 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human breast cancer cell lines using five miRNA microarray platforms
Analysis of hybridisation performance and utility in identifying differentially expressed miRNAs of six miRNA microarray platforms using three biological samples in quadruplicate.
ORGANISM(S): Homo sapiens 
2010-02-24 | E-MTAB-96 | biostudies-arrayexpress
GenomicsNuRD-mediated gene repression in mouse embryonic stem cells
To obtain a global view of NuRD-mediated transcriptional regulation, gene expression profiles of wild-type and Mbd3-null ES cells were compared by microarray analysis. In the absence of Mbd3, which encodes a core structural component of NuRD, the complex does not form and embryonic development stall...
ORGANISM(S): Mus musculus 
2012-03-13 | E-MTAB-888 | biostudies-arrayexpress
TranscriptomicsNuRD-mediated gene repression in mouse embryonic stem cells
To obtain a global view of NuRD-mediated transcriptional regulation, gene expression profiles of wild-type and Mbd3-null ES cells were compared by microarray analysis. In the absence of Mbd3, which encodes a core structural component of NuRD, the complex does not form and embryonic development stall...
ORGANISM(S): Mus musculus 
2012-03-13 | E-MTAB-889 | biostudies-arrayexpress
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