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ProteomicsIdentification of DX2 ubiquitination site
Although ubiquitination of DX2, novel oncogene, is significant on its protein stability, but DX2 ubiquitination sites are not unveiled. In this study, we identified ubiquitination sites of DX2 upon treatment with DX2 protein inhibitor, SDL01, via LC-MSMS technique. Lysine 90 of DX2 was revealed as a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-30 | PXD051772 | Pride
Human Dx2 Uniqutination Cancer cell Lc-ms/ms 
GenomicsStaphylococcus equorum strain:DX2
Staphylococcus equorum strain:DX2 Genome sequencing
PRJNA857830 | ENA
UnknownThe therapeutic effect of DX2 inhibition in nicotine-induced lung cancer progression.
Not available
S-EPMC11439892 | biostudies-literature
UnknownAIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.
Not available
S-EPMC9095880 | biostudies-literature
UnknownAn Isoform of the Oncogenic Splice Variant AIMP2-DX2 Detected by a Novel Monoclonal Antibody.
Not available
S-EPMC7356629 | biostudies-literature
UnknownData on optimization of expression and purification of AIMP2-DX2 protein in Escherichia coli.
Not available
S-EPMC5361769 | biostudies-literature
UnknownSynthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug.
Not available
S-EPMC9621298 | biostudies-literature
UnknownAbsence of Dx2 at Glu-D1 Locus Weakens Gluten Quality Potentially Regulated by Expression of Nitrogen Metabolism Enzymes and Glutenin-Related Genes in Wheat.
Not available
S-EPMC7073084 | biostudies-literature
TranscriptomicsExpression data from adult mouse spleen
AIMP2-DX2 is known as a cancer-associated splicing variant of tumor suppressor, AIMP2, lacking exon 2 (shortly DX2 herein). However, it is not known whether its expression alone can drive tumorigenesis. Here we show that DX2 can induce the expansion of germinal center (GC) origin B lymphocytes and t...
ORGANISM(S): Mus musculus 
2020-05-19 | GSE150733 | GEO
ProteomicsBCDX2-CX3 and DX2-CX3 complexes template RAD51 filament formation
The faithful repair of DNA double-strand breaks by homologous recombination (HR) is essential for genomic integrity, and its dysregulation is a hallmark of cancer. Central to HR is the RAD51 recombinase, whose assembly into a nucleoprotein filament is governed by five RAD51 paralogs (RAD51B, RAD51C,...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-08-04 | MSV000098718 | MassIVE
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